Document Detail


Lindane poisonings.
MedLine Citation:
PMID:  6186202     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
One percent lindane, widely used to treat scabies and pediculosis, presents toxicologic problems when used excessively. A 16-year-old mentally retarded boy accidentally ingested approximately 392 g of 1% lindane shampoo and recovered. A 2-month-old, 4.5-kg, male infant was found dead in his crib after excessive application of a 1% lindane lotion. In the former patient, initial serum levels of lindane were 206 parts per billion (ppb) declining to 1.0 ppb after 25 days. In the latter, lindane was identified in the brain at a concentration of 110 ppb. Brain levels of lindane were three times greater than the levels found in the blood. Although the relationship of this pesticide exposure to the fatal outcome in the second case was conjectural, it was illustrative of the problem of interpreting CNS events that occur shortly after excessive exposure to this insecticide.
Authors:
J E Davies; H V Dedhia; C Morgade; A Barquet; H I Maibach
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Archives of dermatology     Volume:  119     ISSN:  0003-987X     ISO Abbreviation:  Arch Dermatol     Publication Date:  1983 Feb 
Date Detail:
Created Date:  1983-03-11     Completed Date:  1983-03-11     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  0372433     Medline TA:  Arch Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  142-4     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain Chemistry
Humans
Infant
Lindane / analysis,  blood,  poisoning*
Male
Mental Retardation / complications
Scabies / drug therapy,  mortality
Chemical
Reg. No./Substance:
58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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