Document Detail


Lindane (gamma-HCH) causes reproductive failure and fetotoxicity in mice.
MedLine Citation:
PMID:  2479997     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lindane (gamma-Hexachlorocyclohexane) was orally given to pregnant Swiss female mice at various stages of pregnancy. During early pregnancy (1-4 days of gestation), the insecticide caused total absence of any implantation site, while given during mid pregnancy (6-12 days of gestation), lindane caused total resorption of fetuses. Lindane administration during late pregnancy (14-19 days of gestation) resulted in death of all pups either within 12 h (high-dosed group) or 5 days (low-dosed group) of parturition. Body weight of such pups were also highly reduced. When estrogen was given together with lindane at early pregnancy, implantation was normal, although subsequent fetal development was adversely affected. Progesterone, unlike estrogen, could not correct lindane-induced failure in implantation. On the other hand, when estrogen and progesterone were simultaneously given to lindane-fed mice during early pregnancy, both implantation and subsequent fetal development became comparable to normal mice. The insecticide besides being fetotoxic, thus appears to cause steroid hormone deficiency resulting in reproductive and developmental failure.
Authors:
S Sircar; P Lahiri
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Toxicology     Volume:  59     ISSN:  0300-483X     ISO Abbreviation:  Toxicology     Publication Date:  1989 Dec 
Date Detail:
Created Date:  1989-12-27     Completed Date:  1989-12-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0361055     Medline TA:  Toxicology     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-7     Citation Subset:  IM    
Affiliation:
Department of Zoology, University of Calcutta, India.
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MeSH Terms
Descriptor/Qualifier:
Animals
Body Weight / drug effects
Embryo Implantation / drug effects*
Embryonic and Fetal Development / drug effects*
Estrogens / pharmacology
Female
Fetal Death / chemically induced*
Fetal Resorption / chemically induced*
Lindane / toxicity*
Mice
Pregnancy
Progesterone / pharmacology
Teratogens*
Chemical
Reg. No./Substance:
0/Estrogens; 0/Teratogens; 57-83-0/Progesterone; 58-89-9/Lindane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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