| Limits of usual biochemical alcohol markers in cord blood at term: a fetal/maternal population-based study. | |
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MedLine Citation:
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PMID: 17439336 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: After maternal alcohol consumption during pregnancy, many neonates affected by less apparent forms of fetal alcohol syndrome disorder (FASD) do not receive proper diagnosis or treatment. There is thus a need for laboratory markers for early detection of alcohol-exposed neonates. The aim of our study was to assess the efficiency of the usual alcohol biomarkers measured in cord blood to identify alcohol-exposed neonates immediately after birth. METHODS: A 1-year study was conducted in the labor wards of the maternity units of the Auvergne, Central France at the time of term delivery. The patients answered an anonymous self-completion survey concerning alcohol use (Alcohol Use Disorder Identification Test; AUDIT) during their pregnancy. Aspartate aminotransferase, alanine aminotransferase, and gamma-glutamyltransferase concentrations and the percentage of carbohydrate-deficient transferrin were measured in maternal and cord blood. RESULTS: We collected 870 maternal-fetal sample pairs. Two cases (0.2%) of typical FASD were detected. We report a non-significant correlation between maternal and cord blood biomarkers. None of the cord blood biomarkers differed significantly between newborns of alcohol-exposed and unexposed mothers. CONCLUSIONS: We demonstrate that the usual alcohol biomarkers are not effective in cord blood for identifying alcohol-exposed neonates. |
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Authors:
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Denis Gallot; Ingrid de Chazeron; Didier Boussiron; Sylvie Ughetto; Françoise Vendittelli; Franz J Legros; Laurence Roszyk; Pierre-Michel Llorca; Didier Lemery; Vincent Sapin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical chemistry and laboratory medicine : CCLM / FESCC Volume: 45 ISSN: 1434-6621 ISO Abbreviation: Clin. Chem. Lab. Med. Publication Date: 2007 |
Date Detail:
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Created Date: 2007-04-18 Completed Date: 2007-06-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9806306 Medline TA: Clin Chem Lab Med Country: Germany |
Other Details:
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Languages: eng Pagination: 546-8 Citation Subset: IM |
Affiliation:
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Université d'Auvergne, JE2447, ARDEMO, and CHU, Maternité Hôtel-Dieu, Clermont-Ferrand, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood* Ethanol / blood* Female Fetal Blood / chemistry* Humans Infant, Newborn Neonatal Screening* Pregnancy Prospective Studies |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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