Document Detail

Limiting multiple pregnancy in in vitro fertilization/embryo transfer (IVF-ET) cycles.
MedLine Citation:
PMID:  8844309     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Our purpose was to assess how the number of embryos transferred can be adjusted to limit multiple gestations. METHODS: A retrospective analysis of 535 consecutive embryo transfers for the years 1991-1993 was conducted. RESULTS: Fewer than three embryos were associated with a low pregnancy rate. Pregnancy rates were highest in women less than 35 when four or more embryos were transferred. With four or more embryos, multiple gestation pregnancy correlated with the number of high-quality embryos transferred. The risk of triplets and quadruplets was greatest for women less than 40. CONCLUSIONS: Multiple-embryo transfer carries a risk of plural gestation. The risk of multiple pregnancy cannot be eliminated without decreasing the pregnancy rate. The risk of high-order multiple pregnancy was best correlated with the number of good-quality embryos transferred. While all are at risk, patients younger than 40 were at highest risk.
C M Austin; S P Stewart; J M Goldfarb; L A Sheean; V R Gindlesperger; M A Duchon
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  13     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-12-27     Completed Date:  1996-12-27     Revised Date:  2008-03-18    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  540-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, University MacDonald Womens Hospital, Cleveland, Ohio, USA.
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MeSH Terms
Embryo Transfer / methods*
Fertilization in Vitro / methods*
Pregnancy Rate
Pregnancy, Multiple*
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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