Document Detail

Limiting factors of exercise performance 1 year after lung transplantation.
MedLine Citation:
PMID:  17097494     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: After lung transplantation (LTx) exercise capacity frequently remains limited, despite significantly improved pulmonary function. The aim of this study was to evaluate maximal exercise capacity and peripheral muscle force before and 1 year after LTx, and to determine whether peripheral muscle force and lactate threshold (LT) limit exercise capacity 1 year after LTx. METHODS: Twenty-five subjects (mean age 43 years, 8 women and 17 men, 4 single-lung transplantations) were included in the study. Measurements included maximal exercise capacity, lactate threshold (symptom-limited bicycle ergometer test) and muscle force test (hand-held dynamometer) were performed before and 1 year after LTx. RESULTS: Before LTx, all patients showed severe exercise intolerance (mean +/- SD): work capacity (W(peak)), 11.6 +/- 18 W; peak oxygen uptake (Vo(2)), 8.6 +/- 3.6 ml/min/kg. After LTx, exercise capacity improved significantly: W(peak), 69 +/- 27 W (p < 0.001); peak Vo(2), 15.7 +/- 4.3 ml/min/kg (p < 0.001). Ventilatory factors did not appear to limit exercise capacity. Quadriceps muscle force pre- vs post-LTx was: 248 +/- 73 N vs 281 +/- 68 N (p < 0.05). Post-LTx, a significant correlation was found between LT and exercise capacity (r = 0.76, p < 0.001), between muscle force and exercise capacity (r = 0.41, p < 0.05) and between the LT and muscle force (r = 0.53, p < 0.01). CONCLUSIONS: The occurrence of an early and pathologic LT and peripheral muscle weakness contributes to the limitation of exercise capacity and reflects a peripheral deficit post-LTx.
G D Reinsma; N H T ten Hacken; R G Grevink; W van der Bij; G H Koëter; E van Weert
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  25     ISSN:  1557-3117     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-13     Completed Date:  2006-12-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1310-6     Citation Subset:  IM    
Center for Rehabilitation, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. <>
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MeSH Terms
Cohort Studies
Exercise / physiology*
Exercise Test
Exercise Tolerance / physiology*
Lactates / metabolism
Lung / physiology
Lung Transplantation / physiology*
Middle Aged
Muscle Strength Dynamometer
Muscle Weakness / physiopathology*
Muscle, Skeletal / metabolism,  physiology
Oxygen Consumption / physiology
Reg. No./Substance:

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