Document Detail


Limited value of acyclovir in the treatment of uncomplicated herpes zoster: a placebo-controlled study.
MedLine Citation:
PMID:  6392105     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of intravenous acyclovir (at a dosage of 30 mg/kg per day for five days) on uncomplicated herpes zoster was investigated in 51 patients in a double-blind study. Although existing herpes zoster lesions tended to heal more rapidly and new lesions ceased to appear somewhat earlier in the acyclovir group, these differences were not statistically significant. During treatment, patients on acyclovir had significantly lower pain scores than placebo-treated patients. At follow-up, however, there was no difference between the two groups. Complications of herpes zoster occurred only in the placebo groups (generalization in two and keratitis in two cases). With the possible exception of trigeminal zoster or severe pain, acyclovir seems to offer little benefit for immunocompetent patients with herpes zoster.
Authors:
P J van den Broek; J W van der Meer; J D Mulder; J Versteeg; H Mattie
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Infection     Volume:  12     ISSN:  0300-8126     ISO Abbreviation:  Infection     Publication Date:    1984 Sep-Oct
Date Detail:
Created Date:  1985-02-05     Completed Date:  1985-02-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0365307     Medline TA:  Infection     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  338-41     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyclovir / administration & dosage,  therapeutic use*
Adolescent
Adult
Aged
Child
Clinical Trials as Topic
Double-Blind Method
Female
Follow-Up Studies
Herpes Zoster / drug therapy*
Humans
Male
Middle Aged
Pain
Recurrence
Chemical
Reg. No./Substance:
59277-89-3/Acyclovir

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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