Document Detail

Limited validity of o-cresol and benzylmercapturic acid in urine as biomarkers of occupational exposure to toluene at low levels.
MedLine Citation:
PMID:  18716379     Owner:  NLM     Status:  MEDLINE    
This study was initiated to evaluate o-cresol and benzylmercapturic acid in urine in comparison with other biomarkers, as tools to estimate the intensity of occupational exposure to toluene at low levels. In total, 108 solvent exposed workers (engaged in tape production) and 17 non-exposed controls (all men) participated in the study. The surveys were conducted in the second half of working weeks. Diffusive sampling was conducted to measure 8-h time-weighted average intensity of occupational exposure to toluene. Blood and urine samples were collected at the end of a working shift. Blood samples were subjected to analysis for toluene (Tol-B), and urine samples were analyzed for benzyl alcohol (BeOH-U), benzylmercapturic acid (BMA-U), o-cresol (o-CR-U), hippuric acid (HA-U) and toluene (Tol-U) by the methods previously described. The toluene concentrations in workplaces were low in general, with a geometric mean (GM) and the maximum concentration of 1.9 ppm and 8.8 ppm, respectively. The statistical analyses of the six biomarkers for correlation with air-borne toluene showed that both Tol-B and Tol-U gave a high correlation coefficient of 0.58 to 0.61 (p<0.01), whereas the coefficients for BeOH-U and BMA-U together with HA-U were all low (up to 0.22, depending on the correction for urine density) and statistically insignificant (p>0.10) in most cases. o-CR-U had an intermediary coefficient of 0.20 (p<0.05). Comparison with previous publications disclosed that BeOH-U, BMA-U and HA-U correlate with toluene in air when the exposure is intense (e.g., 50 ppm or above), but no longer proportional to air-borne toluene when the exposure is low, e.g., 2 ppm. Such appeared to be also the case for o-CR-U. In over-all evaluation, the validity of o-CR-U in monitoring occupational exposure to toluene at low levels (e.g., 2 ppm) appear to be limited, and BMA-U is not an appropriate biomarker. BeOH-U and HA-U are also inappropriate for this purpose. Only Tol-B and Tol-U may be employed to estimate toluene exposure at low levels.
Osamu Inoue; Toshio Kawai; Hirohiko Ukai; Yuki Maejima; Yoshinari Fukui; Fumiko Ohashi; Satoru Okamoto; Shiro Takada; Haruhiko Sakurai; Masayuki Ikeda
Related Documents :
8947939 - Prenatal cocaine exposure: effects on the development of school-age children.
17565289 - Childhood neurobehavior disinhibition amplifies the risk of substance use disorder: int...
8857699 - The effect of cocaine on myometrial contractile activity: basic mechanisms.
10823349 - Hypoalgesic effect of millimeter waves in mice: dependence on the site of exposure.
1576219 - Potential sources of bias and confounding in environmental epidemiologic studies of pre...
795609 - Local treatment of psoriasis of the scalp with clobetasol propionate and betamethasone-...
10202879 - Comparison of the sperm quality necessary for successful intrauterine insemination with...
11125249 - Apoptosis in maternal peripheral blood during pregnancy.
12114869 - Antenatal diagnosis and obstetric management of cystic hygroma occurring in twin pregna...
Publication Detail:
Type:  Journal Article; Validation Studies    
Journal Detail:
Title:  Industrial health     Volume:  46     ISSN:  1880-8026     ISO Abbreviation:  Ind Health     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985065R     Medline TA:  Ind Health     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  318-25     Citation Subset:  IM    
Tohoku Rosai Hospital, Sendai, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acetylcysteine / analogs & derivatives*,  blood,  urine
Air Pollutants, Occupational / analysis*
Biological Markers
Cresols / blood,  urine*
Middle Aged
Occupational Exposure / analysis*
Toluene / analysis*
Reg. No./Substance:
0/Air Pollutants, Occupational; 0/Biological Markers; 0/Cresols; 108-88-3/Toluene; 19542-77-9/S-benzyl-N-acetyl-L-cysteine; 616-91-1/Acetylcysteine; 95-48-7/2-cresol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Interethnic variability of plasma paraoxonase (PON1) activity towards organophosphates and PON1 poly...
Next Document:  Relationship of nurse burnout with personality characteristics and coping behaviors.