Document Detail

Limited maximal exercise capacity in patients with chronic heart failure: partitioning the contributors.
MedLine Citation:
PMID:  20430267     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: This study aimed to assess the factors limiting maximal exercise capacity in patients with chronic heart failure (CHF). BACKGROUND: Maximal exercise capacity, an important index of health in CHF, might be limited by central and/or peripheral factors; however, their contributions remain poorly understood. METHODS: We studied oxygen (O2) transport and metabolism at maximal cycle (centrally taxing) and knee-extensor (KE) (peripherally taxing) exercise in 12 patients with CHF and 8 healthy control subjects in normoxia and hyperoxia (100% O2). RESULTS: Peak oxygen uptake (VO2) while cycling was 33% lower in CHF patients than in control subjects. By experimental design, peak cardiac output was reduced during KE exercise when compared with cycling (approximately 35%); although muscle mass specific peak leg VO2 was increased equally in both groups (approximately 70%), VO2 in the CHF patients was still 28% lower. Hyperoxia increased O2 carriage in all cases but only facilitated a 7% increase in peak leg VO2 in the CHF patients during cycling, the most likely scenario to benefit from increased O2 delivery. Several relationships, peak leg VO2 (KE + cycle) to capillary-fiber-ratio and capillaries around a fiber to mitochondrial volume, were similar in both groups (r = 0.6-0.7). CONCLUSIONS: Multiple independent observations, including a significant skeletal muscle metabolic reserve, suggest skeletal muscle per se contributes minimally to limiting maximal cycle exercise in CHF or healthy control subjects. However, the consistent attenuation of the convective and diffusive components of O2 transport (25% to 30%) in patients with CHF during both cycle and even KE exercise compared with control subjects reveals an underlying peripheral O2 transport limitation from blood to skeletal muscle in this pathology.
Fabio Esposito; Odile Mathieu-Costello; Ralph Shabetai; Peter D Wagner; Russell S Richardson
Related Documents :
9068397 - The increased ventilatory response to exercise in chronic heart failure: relation to pu...
9313597 - Nitric oxide production during exercise in chronic heart failure.
11790297 - Endothelin antagonists and heart failure.
17222927 - Prognostic impact of peakvo2-changes in stable chf on chronic beta-blocker treatment.
6207807 - Microscopic postmortem changes in kidneys of the domestic fowl.
23999147 - Exercise intensity progression for exercises performed on unstable and stable platforms...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  55     ISSN:  1558-3597     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-04-30     Completed Date:  2010-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1945-54     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Department of Sport, Nutrition and Health Sciences, University of Milan, Milan, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiac Output / physiology
Chronic Disease
Exercise Test
Exercise Tolerance / physiology*
Heart Failure / physiopathology*
Hyperoxia / physiopathology
Middle Aged
Muscle, Skeletal / blood supply,  physiopathology
Norepinephrine / blood
Oxygen / metabolism*
Oxygen Consumption / physiology*
Regional Blood Flow
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intravascular ultrasound findings in patients with very late stent thrombosis after either drug-elut...
Next Document:  Multicenter trial of high-speed versus conventional single-photon emission computed tomography imagi...