Document Detail

Limited fat digestion in infants with bronchopulmonary dysplasia.
MedLine Citation:
PMID:  8642489     Owner:  NLM     Status:  MEDLINE    
In 10 hyaline membrane disease patients with development of bronchopulmonary dysplasia, 16 hyaline membrane disease patients without development of bronchopulmonary dysplasia, and 12 very-low-birthweight infants without major medical problems, we measured the lipase and trypsin activity as well as the bile acids concentrations in preprandially aspirated duodenal juice. In addition, fat and nitrogen balances were performed during the 5th and 6th weeks of postnatal life. The mean duodenal lipase activity in the patients with bronchopulmonary dysplasia was significantly lower than those of the patients without bronchopulmonary dysplasia (4.41 +/- 3.0 versus 9.95 +/- 3.0 U/ml, p < 0.05) and of the controls (19.94 +/- 6.8 U/ml). The mean total bile acid concentration was below the critical micellar concentration of 4 mmol/L only in the patients with bronchopulmonary dysplasia. The fecal fat excretion rate in the patients with bronchopulmonary dysplasia was significantly higher than in the patients without bronchopulmonary dysplasia (21.4 +/- 4.6% versus 11.3 +/- 3.4% of intake, p < 0.01) as well as that of the controls (7.9 +/- 2.8% of intake). The serum urea concentrations were similar in the patients without bronchopulmonary dysplasia and in the controls (1.97 +/- 0.6 and 1.89 +/- 0.4 mmol/L, respectively) but significantly higher in the patients with bronchopulmonary dysplasia (2.54 +/- 0.5 mmol/L). The lowest weight gain was found in the patients with bronchopulmonary dysplasia (8.2 +/- 4.7 g/kg/day). It was significantly lower than one of the patients without bronchopulmonary dysplasia or the controls (13.5 +/- 4.0 and 16.2 +/- 3.7 g/kg/day, respectively). The data indicate that patients who develop bronchopulmonary dysplasia have a limited fat absorption, which may help to explain the inadequate weight gain.
G Boehm; U Bierbach; G Moro; I Minoli
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  22     ISSN:  0277-2116     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-07-12     Completed Date:  1996-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  161-6     Citation Subset:  IM    
Center for Infant Nutrition to Prevent Illnesses in Adult Life, Maternity Hospital Macedonio Melloni, Milan, Italy.
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MeSH Terms
Bile Acids and Salts / analysis,  blood
Bronchopulmonary Dysplasia / etiology,  metabolism*
Dietary Fats / metabolism*
Duodenum / enzymology
Feces / chemistry
Hyaline Membrane Disease / complications,  metabolism
Infant, Newborn
Infant, Very Low Birth Weight / metabolism*,  physiology
Lipase / analysis
Lipid Metabolism*
Lipids / analysis
Nitrogen / analysis,  urine
Pancreas / enzymology
Trypsin / analysis
Urea / blood
Weight Gain / physiology
Reg. No./Substance:
0/Bile Acids and Salts; 0/Dietary Fats; 0/Lipids; 57-13-6/Urea; 7727-37-9/Nitrogen; EC; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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