| Limited T-cell receptor diversity in liver-infiltrating lymphocytes from patients with primary biliary cirrhosis. | |
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MedLine Citation:
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PMID: 8240664 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Primary biliary cirrhosis is associated with the presence of high-titer anti-mitochondrial autoantibodies as well as T-cell infiltration of the liver, suggesting the involvement of autoimmune mechanisms. We have studied here the sequences of T-cell receptor alpha and beta chains expressed by T-cell clones derived from liver-infiltrating lymphocytes of two patients with primary biliary cirrhosis. Among the eight clones studied from the first patient, four expressed the same member of the V beta 6 subfamily, associated with either V alpha 4 (three clones) or V alpha 21 (one clone) gene segment. Two other clones expressed an identical V beta 12 transcript, and two in-frame alpha chain transcripts, involving V alpha 2 and V alpha 7 gene segments. From the second patient, eight out of the nine clones were found to rearrange V beta 17-J beta 2.1 and V alpha 3 gene segments. The remaining clone expressed distinct T-cell receptor chains, involving V beta 9 and V alpha 11 gene segments. As deduced from the analysis of their junctional regions, the eight T-cell clones expressing V beta 17/V alpha 3 gene segments derived from only three different T cells. Furthermore, conserved amino acid motifs were found to be encoded in both the alpha and the beta-chain junctional regions. Together, these data show a local amplification of unique T lymphocytes in both patients. The use of identical V beta J beta and V alpha gene segments with similar junctional sequences by three different cells, evidenced in one of the two cases, strengthens the view that liver-infiltrating T lymphocytes are selected locally by autoantigens in PBC. |
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Authors:
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A Diu; U Moebius; L Ferradini; C Genevée; S Roman-Roman; M Claudon; D Delorme; S Meuer; T Hercend; F Praz |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of autoimmunity Volume: 6 ISSN: 0896-8411 ISO Abbreviation: J. Autoimmun. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1993-12-30 Completed Date: 1993-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8812164 Medline TA: J Autoimmun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 611-9 Citation Subset: IM |
Affiliation:
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Département d'Immunologie, Roussel-Uclaf, Romainville, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amino Acid Sequence Base Sequence Female Humans Liver Cirrhosis, Biliary / immunology* Male Middle Aged Molecular Sequence Data Receptors, Antigen, T-Cell, alpha-beta / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Receptors, Antigen, T-Cell, alpha-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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