Document Detail


Limited Stage Diffuse Large B-Cell Lymphoma: Comparative Effectiveness of Treatment Strategies in a Large Cohort of Elderly Patients.
MedLine Citation:
PMID:  24913508     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract Optimal treatment for limited stage DLBCL in the elderly is controversial. Using the Surveillance Epidemiology and End Results-Medicare database, we compared overall survival (OS), time to second-line therapy (surrogate for recurrence), and adverse events in elderly patients diagnosed with stage I or II DLBCL in 1999-2009, who received either abbreviated rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (RCHOP) plus radiation or 6-8 cycles of RCHOP alone. Of 874 patients, 359 received abbreviated RCHOP with radiation, and 515 received a full course of RCHOP. In propensity score-adjusted analyses, OS was similar in both groups (HR 1.02, 95 CI 0.76,1.38). Abbreviated RCHOP with radiation was associated with lower risk of second-line therapy (HR 0.71, 95% CI 0.53,0.94) and lower odds of febrile neutropenia (OR 0.27, 95% CI 0.15,0.50). While the two treatments resulted in similar survival, our data suggest that abbreviated RCHOP with radiation may be better tolerated than a full course of RCHOP.
Authors:
Oreofe O Odejide; Angel M Cronin; Amy J Davidoff; Ann S LaCasce; Gregory A Abel
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-10
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-27     Citation Subset:  -    
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