| Limited Predictive Value of Dual-Time-Point F-18 FDG PET/CT for Evaluation of Pathologic N1 Status in NSCLC Patients. | |
| | |
MedLine Citation:
|
PMID: 21552019 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
OBJECTIVE: : The aim of the current study was to investigate the predictive value of dual-time-point F-18 FDG PET/CT for pathologic N1 metastasis in patients with non-small cell lung cancer (NSCLC). METHODS: : A retrospective review identified 70 patients with NSCLC patients who received dual-time-point F-18 FDG PET/CT at diagnosis of cancer. The F-18 FDG PET/CT findings for all primary NSCLC and mediastinal lymph node involvement were compared with the pathologic diagnosis within 5 weeks after surgical resection. The pathologic diagnoses of N1 state were confirmed by surgical resection. Univariate and multivariate analyses were used to analyze the associations among the pathologic N1 status and age, sex, tumor size, histology, standardized uptake value (SUVmaxE), SUVmaxD, and %ΔSUVmax. RESULTS: : The N1 (+) group showed statistically significant higher value of SUVmaxE and SUVmaxD than N1 (-) group. The %ΔSUVmax did not show the statistical difference between pathologic N1 (+) and N1 (-) groups. Receiver operating characteristic analyses showed that the SUVmaxE was superior to the %ΔSUVmax for the prediction of pathologic N1 involvement in NSCLC. In univariate analysis, pathology (adenocarcinoma or nonadenocarcinoma), SUVmaxE (>6.9 or ≤6.9), SUVmaxD (>7.1 or ≤7.1) were factors significantly associated with pathologic N1 involvement. However, in multivariate analysis, only the SUVmaxE was factor significantly associated with pathologic N1 involvement in NSCLC. CONCLUSIONS: : Based on the presented results, the dual-time-point F-18 FDG PET/CT is not a useful method for the prediction of pathologic N1 status in NSCLC patients. Further studies are needed to confirm these results and improve statistical accuracy. |
| | |
Authors:
|
Seong-Jang Kim; Yong-Ki Kim; In Joo Kim; Young Dae Kim; Min Ki Lee |
Related Documents
:
|
14697959 - Positron emission tomography for detecting occult hepatocellular carcinoma in hepatitis... 21220969 - F-18 fdg pet/ct for detection of malignant involvement of peripheral nerves: case serie... 21094009 - Ganglia of the tarsal sinus: mr imaging features and clinical findings. 21512049 - Radiation dose reduction for ct-guided renal tumor cryoablation. 16272849 - Eosinophilic hepatic necrosis: magnetic resonance imaging and computed tomography compa... 21094559 - Optimal anatomic coverage for ct in staging lung cancer: lessons from pet-ct correlation. 20677229 - Magnetization transfer ratio mapping of intervertebral disc degeneration. 9795949 - Cystic spinal cord tumors: magnetic resonance imaging correlated to histopathological f... 20817379 - Reproducibility of the gadolinium concentration measurements and of the fitting paramet... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Clinical nuclear medicine Volume: 36 ISSN: 1536-0229 ISO Abbreviation: Clin Nucl Med Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-05-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7611109 Medline TA: Clin Nucl Med Country: United States |
Other Details:
|
Languages: eng Pagination: 434-9 Citation Subset: IM |
Affiliation:
|
From the *Department of Nuclear Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea; †Medical Research Institute, School of Medicine, Pusan National University, Busan, Republic of Korea; ‡Private Clinic of Endocrinology and Metabolism and Nuclear Medicine, Busan, Republic of Korea; and Departments of §Thoracic and Cardiovascular Surgery, and ¶Internal Medicine, School of Medicine, Pusan National University, Busan, Republic of Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Value of Dual-Time-Point FDG PET/CT for Mediastinal Nodal Staging in Non-Small-Cell Lung Cancer Pati...
Next Document: Outpatient radioiodine therapy for thyroid cancer: a safe nuclear medicine procedure.