Document Detail


Limited Influence of Aspirin Intake on Mast Cell Activation in Patients with Food-dependent Exercise-induced Anaphylaxis: Comparison Using Skin Prick and Histamine Release Tests.
MedLine Citation:
PMID:  22068206     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Food-dependent exercise-induced anaphylaxis (FDEIA) is a severe systemic syndrome induced by physical exercise after ingesting causative food. Aspirin is a well-known trigger for anaphylaxis in patients with FDEIA. Possible mechanisms by which symptoms are aggravated by aspirin include enhanced antigen absorption and mast cell activation. The aim of this study was to determine whether aspirin intake has an influence on mast cell/basophil activation in patients with FDEIA. Provocation tests revealed that adding aspirin to the causative food challenge in 7 of 9 (77.8%) patients with FDEIA provoked symptoms. In most cases, pretreatment with aspirin did not enhance skin tests (71.4%) or histamine release tests (88.9%) with food allergen challenges. The study confirmes that histamine release and skin prick tests can be adjunctive tools for diagnosing FDEIA. In addition, our results suggest that exacerbation of FDEIA symptoms by aspirin is not mediated by direct effects of aspirin on mast cell/basophil activation.
Authors:
Atsushi Fukunaga; Hideki Shimizu; Mami Tanaka; Ayuko Kikuzawa; Mariko Tsujimoto; Akiko Sekimukai; Junji Yamashita; Tatsuya Horikawa; Chikako Nishigori
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-9
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  -     ISSN:  0001-5555     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan. E-mail: atsushi@med.kobe-u.ac.jp.
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