Document Detail

Limitations of the use of spectral analysis of heart rate variability for the estimation of cardiac sympathetic activity in heart failure.
MedLine Citation:
PMID:  11271948     Owner:  NLM     Status:  MEDLINE    
Spectral analysis of heart rate variability has gained popularity as a simple, non-invasive tool for assessing autonomic function in both normal subjects and in patients in a variety of clinical settings. However, the use of this method as a means of estimating the magnitude of cardiac sympathetic activation in individual patients with heart failure has proved disappointing, with a lack of concordance with more direct measures of sympathetic outflow. This review will describe the rationale involved in using sympathetic indices obtained from spectral analysis of heart rate variability to assess cardiac sympathetic outflow in normal subjects and patients with heart failure. The specific limitations and technological concerns that dictate how it may most effectively be used in this patient population will be discussed.
C F Notarius; J S Floras
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  3     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2001 Jan 
Date Detail:
Created Date:  2001-02-22     Completed Date:  2001-05-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  29-38     Citation Subset:  IM    
Harrowston Heart Failure Clinic, Division of Cardiology, Mount Sinai and Toronto General Hospitals, University of Toronto, Toronto, Ontario, Canada.
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MeSH Terms
Circadian Rhythm*
Heart Failure / physiopathology*
Heart Rate* / physiology
Sympathetic Nervous System / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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