Document Detail

Limitations of unidimensional indexes of right ventricular contractile function in conscious dogs.
MedLine Citation:
PMID:  10917947     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Our goal was to examine the validity of unidimensional indexes of right ventricular contractile performance in vivo. METHODS: Unidimensional indexes and global measurements of right ventricular volume and contractile performance were compared in 6 conscious dogs. Vena caval occlusions were performed before (control) and during pulmonary arterial or aortic constriction. RESULTS: Moderately strong relationships were demonstrated between right ventricular septal-free wall indexes and global measurements of right ventricular end-diastolic and end-systolic volumes, stroke volume, stroke work, and the slope of the preload recruitable stroke work relationship, respectively, under control conditions (mean r (2) range 0.69-0.94). These relationships were shifted significantly, however, by increased right ventricular afterload. Increased left ventricular afterload significantly shifted the relationships between right ventricular septal-free wall dimensions and end-diastolic and end-systolic volumes. Relationships between the corresponding regional right ventricular free wall segmental indexes and global measurements under control conditions were weaker (mean r (2) range 0.12-0.65) and were significantly more sensitive to distortion by both increased right and left ventricular afterload, the effects of which were generally in opposite directions. These observations are consistent with significant ventricular interactive effects on the relationship between single right ventricular dimensions and right ventricular volume. CONCLUSION: Unidimensional right ventricular measurements are not reliable surrogates for right ventricular volume when assessing right ventricular contractile performance in the intact heart.
M K Karunanithi; M P Feneley
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of thoracic and cardiovascular surgery     Volume:  120     ISSN:  0022-5223     ISO Abbreviation:  J. Thorac. Cardiovasc. Surg.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-08-30     Completed Date:  2000-08-30     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376343     Medline TA:  J Thorac Cardiovasc Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  302-12     Citation Subset:  AIM; IM    
Victor Chang Cardiac Research Institute and Cardiology Department, St Vincent's Hospital, Darlinghurst, New South Wales, Australia.
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MeSH Terms
Blood Pressure
Linear Models
Myocardial Contraction / physiology*
Stroke Volume
Ventricular Function, Right / physiology*

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