Document Detail

Limitations to plasticity of language network reorganization in localization related epilepsy.
MedLine Citation:
PMID:  19059978     Owner:  NLM     Status:  MEDLINE    
Neural networks for processing language often are reorganized in patients with epilepsy. However, the extent and location of within and between hemisphere re-organization are not established. We studied 45 patients, all with a left hemisphere seizure focus (mean age 22.8, seizure onset 13.3), and 19 normal controls (mean age 24.8) with an fMRI word definition language paradigm to assess the location of language processing regions. Individual patient SPM maps were compared to the normal group in a voxel-wise comparison; a voxel was considered to be significant if its z-value exceeded mid R:2mid R:. Subsequently, we used principal component analysis with hierarchical clustering of variance patterns from individual difference maps to identify four patient sub-groups. One did not differ from normal controls; one had increased left temporal activation on the margin of regions activated in controls; two others had recruitment in right inferior frontal gyrus, middle frontal gyrus and temporal cortex. Right hemisphere activation in these two groups occurred in homologues of left hemisphere regions that sustained task activation. Our study used novel data driven methods to find evidence for constraints on inter-hemispheric reorganization of language in recruitment of right homologues, and, in a subpopulation of patients, evidence for intra-hemispheric reorganization of language limited to the margins of typical left temporal regional activation. These methods may be applied to investigate both normal and pathological variance in other developmental disorders and cognitive domains.
J Mbwana; M M Berl; E K Ritzl; L Rosenberger; J Mayo; S Weinstein; J A Conry; P L Pearl; S Shamim; E N Moore; S Sato; L G Vezina; W H Theodore; W D Gaillard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-12-05
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  132     ISSN:  1460-2156     ISO Abbreviation:  Brain     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-11     Completed Date:  2009-03-10     Revised Date:  2013-06-04    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  England    
Other Details:
Languages:  eng     Pagination:  347-56     Citation Subset:  AIM; IM    
Department of Neuroscience, Children's National Medical Center, Washington, District of Columbia 20010, USA.
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MeSH Terms
Brain Mapping
Case-Control Studies
Epilepsy / physiopathology*
Image Processing, Computer-Assisted*
Magnetic Resonance Imaging / methods
Middle Aged
Nerve Net / physiopathology*
Neuronal Plasticity
Neuropsychological Tests
Principal Component Analysis
Young Adult
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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