Document Detail

Limitations of qualitative serum beta-HCG assays in the diagnosis of ectopic pregnancy.
MedLine Citation:
PMID:  6198517     Owner:  NLM     Status:  MEDLINE    
Seventy-four patients had ectopic pregnancies proven by surgery. Three of them had a serum beta-HCG test for pregnancy that was reported as negative (less than 25-35 mIU/ml). We sought a threshold for positive in the serum beta-HCG test that would maximize its usefulness in diagnosing ectopic pregnancy. Sera from 52 of the patients were available for reanalysis. Quantitative values of beta-HCG were determined. Lowering the threshold for positive from 25-35 to 10 mIU/ml might increase the test's sensitivity without sacrificing specificity but would still not ensure detection of all ectopic pregnancies. Of 445 cases of ectopic pregnancy described in the literature, 6 had serum beta-HCG values reported as negative. In the published reports and in our own cases, clinical histories and histologies indicated that a nonviable ectopic pregnancy can be expected to have an associated serum concentration of beta-HCG that may be below the sensitivity of detection even with current, commercially available quantitative tests.
C M Olson; J A Holt; E Alenghat; S Greco; J R Lumpkin; G D Geanon
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of reproductive medicine     Volume:  28     ISSN:  0024-7758     ISO Abbreviation:  J Reprod Med     Publication Date:  1983 Dec 
Date Detail:
Created Date:  1984-03-01     Completed Date:  1984-03-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0173343     Medline TA:  J Reprod Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  838-42     Citation Subset:  IM    
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MeSH Terms
Chorionic Gonadotropin / blood*
Chorionic Gonadotropin, beta Subunit, Human
Peptide Fragments / blood*
Pregnancy Tests, Immunologic
Pregnancy, Ectopic / diagnosis*
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Chorionic Gonadotropin, beta Subunit, Human; 0/Peptide Fragments

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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