| Limitations of monotherapy trials in epilepsy. | |
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MedLine Citation:
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PMID: 12796518 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Monotherapy is considered optimal management for most patients with epilepsy, but designing monotherapy trials in epilepsy has proved to be a complex endeavor. Consideration of the validity of evidence for efficacy, potential risks to patients, clinical applicability of results, and effects of dosing and titration rates on efficacy and tolerability creates unique challenges. This article reviews pertinent aspects of trials of conversion to monotherapy in refractory patients and equivalence trials in newly diagnosed patients to better understand their limitations. Despite the inherent difficulties in designing monotherapy trials in epilepsy, previous monotherapy studies have provided important information for clinical management with new treatments. |
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Authors:
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Frank G Gilliam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Neurology Volume: 60 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-10 Completed Date: 2004-01-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: S26-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Washington University Epilepsy Program, Washington University, St. Louis, MO 63110, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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adverse effects,
therapeutic use* Clinical Trials as Topic / ethics, statistics & numerical data Dose-Response Relationship, Drug Epilepsy / drug therapy* Ethics, Clinical Humans Patient Dropouts Reproducibility of Results Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
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NS01794/NS/NINDS NIH HHS; NS40808/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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