| Limitations of PET/CT in determining need for neck dissection after primary chemoradiation for advanced head and neck squamous cell carcinoma. | |
| | |
MedLine Citation:
|
PMID: 19776658 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The purpose of our study was to evaluate PET/CT in predicting residual nodal disease after primary chemoradiation (CRT) for head and neck cancer (HNSCC) with N2 disease or greater. DESIGN: A retrospective cohort analysis was conducted. Thirty-eight patients received primary CRT for HNSCC with N2 or greater disease, PET/CT after treatment and neck dissection from January 2003 to December 2006. PET/CT results were correlated with pathology results from neck dissection specimens for each respective side. RESULTS: Forty-six neck regions were analyzed. Nine were determined to have either PET/CT result reports (n = 5) or pathology reports (n = 4) that were indeterminate. PET/CT demonstrated a sensitivity and specificity of 57.1 and 73.9%, respectively, an accuracy of 67.5%, a positive predictive value of 57.1% and a negative predictive value of 73.9% when compared to the final pathology. CONCLUSION: PET/CT is neither highly sensitive nor highly specific for identifying residual nodal metastases after CRT for advanced-stage HNSCC. Physicians should not rely solely on PET/CT to determine interventions on the neck after CRT. A standardization of language for reporting findings and risk of residual disease is needed. |
| | |
Authors:
|
Sofia Lyford-Pike; Patrick K Ha; Heather A Jacene; John R Saunders; Ralph P Tufano |
Related Documents
:
|
19910448 - Fluorodeoxyglucose-positron-emission tomography imaging of head and neck squamous cell ... 19333688 - Role of carbon-11 choline pet/ct in the management of uterine carcinoma: initial experi... 17684588 - Fluoro-18 fluorodeoxyglucose positron emission tomography/computerized tomography scans... 18550578 - Combined pet and low-dose, noncontrast ct scanning obviates the need for additional dia... 2123988 - Different imaging methods in the assessment of radiation-induced lung injury following ... 12027578 - Postictal mixed transcortical aphasia. |
Publication Detail:
|
Type: Journal Article Date: 2009-09-16 |
Journal Detail:
|
Title: ORL; journal for oto-rhino-laryngology and its related specialties Volume: 71 ISSN: 1423-0275 ISO Abbreviation: ORL J. Otorhinolaryngol. Relat. Spec. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-12-03 Completed Date: 2010-02-17 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0334721 Medline TA: ORL J Otorhinolaryngol Relat Spec Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 251-6 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 S. Karger AG, Basel. |
Affiliation:
|
Department of Nuclear Medicine, Greater Baltimore Medical Center, Baltimore, MD, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Squamous Cell / diagnosis*, radiotherapy, surgery* Combined Modality Therapy Female Head and Neck Neoplasms / diagnosis*, radiotherapy, surgery* Humans Male Middle Aged Neoplasm, Residual / diagnosis, radiotherapy, surgery Pharyngeal Neoplasms / diagnosis, radiotherapy, surgery Positron-Emission Tomography* Predictive Value of Tests Retrospective Studies Sensitivity and Specificity Tomography, X-Ray Computed* Tongue Neoplasms / diagnosis, radiotherapy, surgery Tonsillar Neoplasms / diagnosis, radiotherapy, surgery Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Time between Symptom Onset and Assessment in Age-Related Macular Degeneration with Subfoveal Choroid...
Next Document: Influence of NR2B-selective NMDA antagonist on lindane-induced seizures in rats.