| Limitations of collateral flow after occlusion of a single cortical penetrating arteriole. | |
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MedLine Citation:
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PMID: 20842163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Occlusions of penetrating arterioles, which plunge into cortex and feed capillary beds, cause severe decreases in blood flow and are potential causes of ischemic microlesions. However, surrounding arterioles and capillary beds remain flowing and might provide collateral flow around the occlusion. We used femtosecond laser ablation to trigger clotting in single penetrating arterioles in rat cortex and two-photon microscopy to measure changes in microvessel diameter and red blood cell speed after the clot. We found that after occlusion of a single penetrating arteriole, nearby penetrating and surface arterioles did not dilate, suggesting that alternate blood flow routes are not actively recruited. In contrast, capillaries showed two types of reactions. Capillaries directly downstream from the occluded arteriole dilated after the clot, but other capillaries in the same vicinity did not dilate. This heterogeneity in capillary response suggests that signals for vasodilation are vascular rather than parenchymal in origin. Although both neighboring arterioles and capillaries dilated in response to topically applied acetylcholine after the occlusion, the flow in the territory of the occluded arteriole did not improve. Collateral flow from neighboring penetrating arterioles is neither actively recruited nor effective in improving blood flow after the occlusion of a single penetrating arteriole. |
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Authors:
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Nozomi Nishimura; Nathanael L Rosidi; Costantino Iadecola; Chris B Schaffer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-01 Completed Date: 2010-12-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1914-27 Citation Subset: IM |
Affiliation:
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Department of Biomedical Engineering, Cornell University, Ithaca, New York, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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pharmacology Animals Arterioles / drug effects Brain / blood supply*, drug effects Intracranial Thrombosis* Male Rats Rats, Sprague-Dawley Vasodilator Agents / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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NS37853/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 51-84-3/Acetylcholine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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