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Limitations of Biomarkers Serum Levels During Pulmonary Vein Isolation.
MedLine Citation:
PMID:  21237551     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
INTRODUCTION AND OBJECTIVES: Several biomarkers have been used for evaluation and quantification of myocardial injury after effective ablation. We studied possible different thermal stability and usability of the proteins released by cardiac cells injured by different energy sources. METHODS: Firstly, we tested in vitro thermal stability of creatinine kinase (CK), myocardial bound creatinine kinase (CKMB), cardiac troponins I (cTnI) and cardiac troponins T (cTnT) in collected blood samples from 15 patients (pts) with confirmed ST-segment elevated myocardial infarction (STEMI). Secondly, the biomarkers were collected and analyzed in 82 pts treated with radiofrequency ablation (RFA) and in 79 pts treated with cryo-balloon ablation (CBA). RESULTS: In vitro experiment showed that all biomarkers were stable in low temperature of -30(o)C. Troponins were stable in the high temperatures analyzed. A substantial drop in CK and CKMB levels were measured at 50°C and 40° C, respectively. In vivo study showed that the increase in CKMB levels was highly significant in CBA pts only. Pathological CKMB values were observed in 24% of RFA pts and 98% of CBA pts. Pathological cTnI values were observed in all pts and the rise in cTnI levels was highly significant in both groups after ablation. CONCLUSIONS: Both in vitro and in vivo results show that CKMB cannot be used for quantitative determination of myocardial injury produced by radiofrequency energy. Only cardiac troponins reflect myocardial injury, regardless of energy source, and may be considered in future studies for comparison of biomarkers effects of cryo versus radiofrequency ablation. Full English text available from: www.revespcardiol.org.
Authors:
Maciej Wojcik; Sebastien Janin; Malte Kuniss; Alexander Berkowitsch; Damir Erkapic; Sergey Zaltsberg; Katherina Madlener; Andrzej Wysokinski; Christian W Hamm; Heinz F Pitschnera; Thomas Neumann
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-17
Journal Detail:
Title:  Revista espanola de cardiologia     Volume:  64     ISSN:  1579-2242     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404277     Medline TA:  Rev Esp Cardiol     Country:  -    
Other Details:
Languages:  ENG; SPA     Pagination:  127-132     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.
Affiliation:
Departamento de Cardiología, Centro Cardiológico Kerckhoff, Bad Nauheim, Alemania; Departamento de Cardiología, Universidad de Medicina de Lublin, Lublin, Polonia.
Vernacular Title:
Limitaciones de la determinación de los niveles de los biomarcadores séricos durante el aislamiento de venas pulmonares.
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