| Limbic response to psychosocial stress in schizotypy: A functional magnetic resonance imaging study. | |
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MedLine Citation:
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PMID: 21705195 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Psychological stress causes dopamine release in the striatum and is thought to play a role in susceptibility to psychotic illness. Previous work suggests that an elevated dopaminergic response to stress may index vulnerability to psychosis in certain individuals. With functional magnetic resonance imaging, we measured stress-induced changes in brain activity in healthy individuals at elevated risk of developing psychosis. Participants were 15 controls and 25 psychometric schizotypes: 12 with positive symptom schizotypy (perceptual aberrations) and 13 with negative symptom schizotypy (physical anhedonia), as determined by questionnaires (Chapman et al., 1976; Chapman and Chapman, 1978). In the scanner, participants performed the Montreal Imaging Stress Task and a matched sensory-motor control task. Measures of self-reported stress and salivary cortisol levels were taken throughout the experiment. All three groups showed significant increases in self-reported stress and significant fMRI signal change in the striatal, limbic and cortical regions. However, the Physical Anhedonia group showed greater stress-induced striatal and limbic deactivation than the other two groups. Deactivation in the striatum was significantly correlated with Physical Anhedonia score across all subjects. Our findings suggest the presence of abnormalities in striatal response to stress in negative symptom schizotypy. |
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Authors:
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Alexandra Soliman; Gillian A O'Driscoll; Jens Pruessner; Ridha Joober; Blaine Ditto; Elizabeth Streicker; Yael Goldberg; Josie Caro; P Vivien Rekkas; Alain Dagher |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-24 |
Journal Detail:
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Title: Schizophrenia research Volume: - ISSN: 1573-2509 ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804207 Medline TA: Schizophr Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier B.V. All rights reserved. |
Affiliation:
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McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, Montreal, Canada; Department of Psychology, McGill University, Montreal, Canada; Vivian M. Rakoff PET Imaging Center, Center for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, ON, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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