| Limbic encephalitis presenting with seizures, anterograde amnesia, and psychosis in a patient seven weeks status post immature ovarian teratoma removal. | |
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MedLine Citation:
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PMID: 20731268 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A paraneoplastic syndrome associated with anti-N-methyl-D-asparate (NMDA) receptors can initially present as a neurologic or psychiatric disturbance. Removal of the tumor is usually curative, and the syndrome is associated with the presence, rather than the history, of tumor. We present a case in which a 25-year-old, Hispanic woman presented with seizures, memory loss, and unusual behavioral changes. The woman had a teratoma removed 2 months earlier. Because of the time course, a paraneoplastic syndrome was initially considered unlikely. Brain imaging, electroencephalography (EEG) and neurologic work-up were negative. The patient was treated for a suspected somatoform disorder and psychosis. Based on the clinical picture, the working diagnosis was changed to delirium due to paraneoplastic limbic encephalitis. A course of intravenous immunoglobins (IVIg), and high dose steroids was administered. The patient's symptoms improved, and she was discharged home. After discharge, studies came back positive for antibodies against NR1/NR2 of the NMDA receptor. |
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Authors:
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Brian Kleyensteuber; Victor Ruterbusch; Jason Bennett; David Llewellyn; George Loeffler |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Military medicine Volume: 175 ISSN: 0026-4075 ISO Abbreviation: Mil Med Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-24 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2984771R Medline TA: Mil Med Country: United States |
Other Details:
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Languages: eng Pagination: 616-8 Citation Subset: IM |
Affiliation:
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Department of Mental Health, Naval Medical Center San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amnesia, Anterograde / diagnosis*, drug therapy Diagnosis, Differential Diagnostic Imaging Electroencephalography Female Humans Immunoglobulins, Intravenous / therapeutic use Limbic Encephalitis / diagnosis*, drug therapy Ovarian Neoplasms / surgery Paraneoplastic Syndromes / diagnosis*, drug therapy Psychotic Disorders / diagnosis*, drug therapy Seizures / diagnosis*, drug therapy Steroids / therapeutic use Teratoma / surgery |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins, Intravenous; 0/Steroids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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