Document Detail

Limbal lymphangiogenesis after corneal injury: an autoradiographic study.
MedLine Citation:
PMID:  2707040     Owner:  NLM     Status:  MEDLINE    
Blood and lymphatic vessel proliferation into the cornea occurs after severe trauma. Whilst the events early in blood vessel growth are reasonably understood, little is known of the early events in lymphangiogenesis. In this study, a model for proliferating lymphatic vessels using tritiated-thymidine autoradiography and light microscopy is described. A two-hour labeling index of 0.59% occurred in the lymphatic endothelium of the normal unstimulated limbus. After thermal cautery of the peripheral cornea, labeling of the limbal lymphatic vessels increased significantly at 36 hours, rose to a maximum of 6.8% four days after injury and thereafter returned to normal levels. Blood capillaries with a background level of 0.83% showed an increase in labeling at 17 hours, with high levels occurring at 36 hours (13.6%) and again from 61 to 84 hours (12.6%). Venular cells increased labeling at 25 hours from a control level of 0.58%, with a sharp peak of activity around 36 hours (13.2%). Synthesis of DNA similarly returned to normal levels in the blood vessels after four days. The staggered onset and differing durations of significantly increased labeling suggest either that various stimuli or arrays of stimuli are involved, or each cell type responds differently to the same stimulus for proliferation.
B M Junghans; H B Collin
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current eye research     Volume:  8     ISSN:  0271-3683     ISO Abbreviation:  Curr. Eye Res.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8104312     Medline TA:  Curr Eye Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  91-100     Citation Subset:  IM    
School of Optometry, University of New South Wales, Kensington, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cornea / injuries*
Endothelium, Lymphatic / pathology
Lymphatic System / pathology*
Rats, Inbred Strains
Time Factors
Wounds, Nonpenetrating / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Modification and calibration of the Bigliano-Webb Tonometer for improved accuracy of tonometry in ra...
Next Document:  Quantitative analysis of labelled inner retinal proteins in experimental optic neuritis.