Document Detail


Limb venous distension evokes sympathetic activation via stimulation of the limb afferents in humans.
MedLine Citation:
PMID:  22707559     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We have recently shown that a saline infusion in the veins of an arterially occluded human forearm evokes a systemic response with increases in muscle sympathetic nerve activity (MSNA) and blood pressure. In this report, we examined whether this response was a reflex that was due to venous distension. Blood pressure (Finometer), heart rate, and MSNA (microneurography) were assessed in 14 young healthy subjects. In the saline trial (n = 14), 5% forearm volume normal saline was infused in an arterially occluded arm. To block afferents in the limb, 90 mg of lidocaine were added to the same volume of saline in six subjects during a separate visit. To examine whether interstitial perfusion of normal saline alone induced the responses, the same volume of albumin solution (5% concentration) was infused in 11 subjects in separate studies. Lidocaine abolished the MSNA and blood pressure responses seen with saline infusion. Moreover, compared with the saline infusion, an albumin infusion induced a larger (MSNA: Δ14.3 ± 2.7 vs. Δ8.5 ± 1.3 bursts/min, P < 0.01) and more sustained MSNA and blood pressure responses. These data suggest that venous distension activates afferent nerves and evokes a powerful systemic sympathoexcitatory reflex. We posit that the venous distension plays an important role in evoking the autonomic adjustments seen with postural stress in human subjects.
Authors:
Jian Cui; Patrick M McQuillan; Cheryl Blaha; Allen R Kunselman; Lawrence I Sinoway
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-06-15
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  303     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2012-10-26     Revised Date:  2013-08-18    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H457-63     Citation Subset:  IM    
Affiliation:
Pennsylvania State University College of Medicine, Penn State Hershey Heart & Vascular Institute, Hershey, PA 17033, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Afferent Pathways / physiopathology
Albumins / administration & dosage
Analysis of Variance
Anesthetics, Local / administration & dosage
Blood Pressure* / drug effects
Female
Heart Rate
Humans
Infusions, Intravenous
Ischemia / physiopathology*
Lidocaine / administration & dosage
Lower Extremity
Male
Muscle, Skeletal / innervation*
Pennsylvania
Reflex* / drug effects
Respiratory Rate
Sodium Chloride / administration & dosage
Sympathetic Nervous System / drug effects,  physiopathology*
Time Factors
Upper Extremity / blood supply*,  innervation*
Veins / physiopathology
Venous Pressure
Grant Support
ID/Acronym/Agency:
C06 RR-016499/RR/NCRR NIH HHS; P01 HL-096570/HL/NHLBI NIH HHS; P01 HL096570/HL/NHLBI NIH HHS; UL1 RR-033184/RR/NCRR NIH HHS; UL1 TR000127/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Albumins; 0/Anesthetics, Local; 137-58-6/Lidocaine; 7647-14-5/Sodium Chloride
Comments/Corrections

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