| Limb-specific and cross-transfer effects of arm-crank exercise training in patients with symptomatic peripheral arterial disease. | |
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MedLine Citation:
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PMID: 19388883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Arm cranking is a useful alternative exercise modality for improving walking performance in patients with intermittent claudication; however, the mechanisms of such an improvement are poorly understood. The main aim of the present study was to investigate the effects of arm-crank exercise training on lower-limb O2 delivery in patients with intermittent claudication. A total of 57 patients with intermittent claudication (age, 70+/-8 years; mean+/-S.D.) were randomized to an arm-crank exercise group or a non-exercise control group. The exercise group trained twice weekly for 12 weeks. At baseline and 12 weeks, patients completed incremental tests to maximum exercise tolerance on both an arm-crank ergometer and a treadmill. Respiratory variables were measured breath-by-breath to determine peak VO2 (O2 uptake) and ventilatory threshold. Near-IR spectroscopy was used in the treadmill test to determine changes in calf muscle StO2 (tissue O2 saturation). Patients also completed a square-wave treadmill-walking protocol to determine VO2 kinetics. A total of 51 patients completed the study. In the exercise group, higher maximum walking distances (from 496+/-250 to 661+/-324 m) and peak VO2 values (from 17.2+/-2.7 to 18.2+/-3.4 ml.kg-1 of body mass.min-1) were recorded in the incremental treadmill test (P<0.05). After training, there was also an increase in time to minimum StO2 (from 268+/-305 s to 410+/-366 s), a speeding of VO2 kinetics (from 44.7+/-10.4 to 41.3+/-14.4 s) and an increase in submaximal StO2 during treadmill walking (P<0.05). There were no significant changes in the control group. The results suggest that the improvement in walking performance after arm-crank exercise training in patients with intermittent claudication is attributable, at least in part, to improved lower-limb O2 delivery. |
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Authors:
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Garry Tew; Shah Nawaz; Irena Zwierska; John M Saxton |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-09-21 |
Journal Detail:
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Title: Clinical science (London, England : 1979) Volume: 117 ISSN: 1470-8736 ISO Abbreviation: Clin. Sci. Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-09-21 Completed Date: 2009-12-01 Revised Date: 2010-02-22 |
Medline Journal Info:
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Nlm Unique ID: 7905731 Medline TA: Clin Sci (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 405-13 Citation Subset: IM |
Affiliation:
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Centre for Sport and Exercise Science, Sheffield Hallam University, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Arm / physiopathology* Exercise Test / methods Exercise Therapy / methods* Exercise Tolerance / physiology Humans Intermittent Claudication / physiopathology, rehabilitation* Lower Extremity / blood supply Middle Aged Muscle, Skeletal / blood supply Oxygen Consumption / physiology Pulmonary Gas Exchange / physiology Treatment Outcome Walking / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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