| Limb salvage following laser-assisted angioplasty for critical limb ischemia: results of the LACI multicenter trial. | |
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MedLine Citation:
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PMID: 16445313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate the effectiveness of laser-assisted angioplasty for patients with critical limb ischemia (CLI) who were poor candidates for surgical revascularization. METHODS: A prospective registry at 14 sites in the US and Germany enrolled 145 patients with 155 critically ischemic limbs; the patients were poor candidates for bypass surgery owing to inadequate target vessel or saphenous vein, prohibitive cardiac disease, or significant comorbidities (ASA class 4). Additional comorbid risk factors included diabetes in 66%, hypertension in 83%, previous stroke in 21%, and myocardial infarction in 23%. Endovascular treatment included guidewire traversal and excimer laser angioplasty followed by balloon angioplasty with optional stenting. RESULTS: Occlusions were present in 92% of limbs. A mean of 2.7+/-1.4 lesions were treated per limb; the total median treatment length was 11 cm (mean 16.2, range 0.2-123). Stents were implanted in 45% of limbs. Procedural success, defined as <50% residual stenosis in all treated lesions, was seen in 86% of limbs. At 6-month follow-up, limb salvage was achieved in 110 (92%) of 119 surviving patients or 118 (93%) 127 limbs. CONCLUSION: Excimer laser-assisted angioplasty for CLI offers high technical success and limb salvage rates in patients unfit for traditional surgical revascularization. |
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Authors:
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John R Laird; Thomas Zeller; Bruce H Gray; Dierk Scheinert; Mitar Vranic; Christopher Reiser; Giancarlo Biamino; |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists Volume: 13 ISSN: 1526-6028 ISO Abbreviation: J. Endovasc. Ther. Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-31 Completed Date: 2006-06-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100896915 Medline TA: J Endovasc Ther Country: United States |
Other Details:
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Languages: eng Pagination: 1-11 Citation Subset: IM |
Affiliation:
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Washington Hospital Center, Washington, DC 20010, USA, and Herzzentrum, Universität Leipzig, Germany. John.R.Laird@medstar.net |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Amputation Angioplasty, Balloon, Laser-Assisted* / adverse effects Arterial Occlusive Diseases / complications, surgery Critical Illness Female Femoral Artery / radiography Follow-Up Studies Foot Ulcer / complications, pathology, surgery Humans Ischemia / etiology, mortality, surgery* Leg / blood supply*, radiography Limb Salvage* Male Patient Selection Popliteal Artery / radiography Stents Survival Rate Tibial Arteries / radiography |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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