Document Detail


Limb neurovascular control during altered otolithic input in humans.
MedLine Citation:
PMID:  11773337     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Head-down rotation (HDR), which activates the vestibulosympathetic reflex, increases leg muscle sympathetic nerve activity (MSNA) and produces calf vasoconstriction with no change in either cardiac output or arterial blood pressure. Based on animal studies, it was hypothesized that differential control of arm and leg MSNA explains why HDR does not alter arterial blood pressure. Fifteen healthy subjects were studied. Heart rate, arterial blood pressure, forearm and calf blood flow, and leg MSNA responses were measured during HDR in these subjects. Simultaneous recordings of arm and leg MSNA were obtained from five of the subjects. Forearm and calf blood flow, vascular conductances, and vascular resistances were similar before HDR, as were arm and leg MSNA. HDR elicited similar significant increases in leg (Delta 6 +/- 1 bursts min(-1); 59 +/- 16 % from baseline) and arm MSNA (Delta 5 +/- 1 bursts min(-1); 80 +/- 28 % from baseline). HDR significantly decreased calf (-19 +/- 2 %) and forearm vascular conductance (-12 +/- 2 %) and significantly increased calf (25 +/- 4 %) and forearm vascular resistance (15 +/- 2 %), with ~60 % greater vasoconstriction in the calf than in the forearm. Arterial blood pressure and heart rate were not altered by HDR. These results indicate that there is no differential control of MSNA in the arm and leg during altered feedback from the otolith organs in humans, but that greater vasoconstriction occurs in the calf than in the forearm. These findings indicate that vasodilatation occurs in other vascular bed(s) to account for the lack of increase in arterial blood pressure during HDR.
Authors:
Kevin D Monahan; Chester A Ray
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  538     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-04     Completed Date:  2002-03-14     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  303-8     Citation Subset:  IM; S    
Affiliation:
Department of Medicine (Cardiology), General Clinical Research Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Forearm*
Head / physiology
Humans
Leg*
Male
Muscle, Skeletal / blood supply*,  innervation*
Otolithic Membrane / physiology*
Posture / physiology
Regional Blood Flow / physiology
Rotation
Sympathetic Nervous System / physiology*
Vascular Resistance / physiology
Vasoconstriction / physiology
Grant Support
ID/Acronym/Agency:
HL58303/HL/NHLBI NIH HHS; HL67624/HL/NHLBI NIH HHS; M01 RR10732/RR/NCRR NIH HHS
Investigator
Investigator/Affiliation:
C A Ray / PA St U Coll Med, Hershey
Comments/Corrections

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