| Limb movement-induced hyperemia has a central hemodynamic component: evidence from a neural blockade study. | |
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MedLine Citation:
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PMID: 20802133 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this investigation was to partially remove feedback from type III/IV skeletal muscle afferents and determine how this feedback influences the central and peripheral hemodynamic responses to passive leg movement. Heart rate (HR), stroke volume (SV), cardiac output (CO), mean arterial pressure, leg vascular conductance (LVC), and leg blood flow (LBF) were measured during 2 min of passive knee extension in eight young men before and after intrathecal fentanyl injection. Passive movement increased HR by 14 beats/min from baseline to maximal response during control (CON) (65 ± 4 to 79 ± 5 beats/min, P < 0.05), whereas HR did not significantly increase with the fentanyl block (BLK). LBF and LVC increased in both conditions; however, these increases were attenuated and delayed during BLK [%change from baseline to maximum, LBF: CON 295 ± 109 vs. BLK 210 ± 86%, (P < 0.05); LVC: CON 322 ± 40% vs. BLK 231 ± 32%, (P < 0.04)]. In CON, HR, SV, CO, and LVC increased contributing to the hyperemic response. However, under BLK conditions, statistically insignificant increases in HR and SV combined to yield a small, but significant, increase in CO and an attenuated hyperemic response. Therefore, partially blocking skeletal muscle afferent feedback blunts the central hemodynamic response due to passive limb movement, which then results in an attenuated and delayed movement-induced hyperemia. In combination, these findings provide evidence that limb movement-induced hyperemia has a significant central hemodynamic component induced by peripheral nerve activation. |
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Authors:
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Joel D Trinity; Markus Amann; John McDaniel; Anette S Fjeldstad; Zachary Barrett-O'Keefe; Sean Runnels; David E Morgan; D Walter Wray; Russell S Richardson |
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Publication Detail:
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Type: Journal Article Date: 2010-08-27 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 299 ISSN: 1522-1539 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-01 Completed Date: 2010-11-29 Revised Date: 2011-04-19 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1693-700 Citation Subset: IM |
Affiliation:
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Geriatric Research, Education, and Clinical Center, George E. Whalen Veterans Affairs Medical Center, Salt Lake City, Utah, USA. joel.trinity@utah.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / pharmacology Blood Pressure / drug effects, physiology Cardiac Output / drug effects, physiology Feedback Fentanyl / pharmacology Heart Rate / drug effects, physiology Hemodynamics / physiology* Humans Hyperemia / physiopathology* Leg / blood supply, physiology* Male Movement / physiology* Muscle Contraction / drug effects, physiology Muscle, Skeletal / drug effects, innervation, physiology Peripheral Nerves / physiology* Regional Blood Flow / drug effects, physiology Stroke Volume / drug effects, physiology |
| Grant Support | |
ID/Acronym/Agency:
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K99 HL103786-01/HL/NHLBI NIH HHS; K99 HL103786-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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