Document Detail

Limb ischemic postconditioning protects myocardium from ischemia-reperfusion injury.
MedLine Citation:
PMID:  17012143     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that limb ischemic postconditioning protects the myocardium from reperfusion injury, and examine the mechanism involved. DESIGN: Forty rabbits were randomly divided into four groups: Control, Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning. Myocardial infarct size and tissue myeloperoxidase activity were determined at the end of the experiment. Plasma creatine kinase and malondialdehyde activity were measured at baseline, the end of ischemia, and after 3 h of reperfusion respectively. RESULTS: Myocardial infarct size was significantly reduced in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning as compared to Control (p < 0.01). Results were confirmed by plasma creatine kinase activity. Plasma malondialdehyde was significantly less at 3 h of reperfusion in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01). Neutrophil accumulation (myeloperoxidase activity) in the area at risk was less in Ischemic Preconditioning, Ischemic Postconditioning and Remote Postconditioning than that in Control (p < 0.01). CONCLUSION: Remote postconditioning reduces myocardial infarction in rabbits. The mechanism involved might be reduced oxygen radical-induced injury and improved antioxidant action.
Chun-Mei Li; Xing-Hua Zhang; Xiao-Jing Ma; Man Luo
Related Documents :
18691153 - Pharmacological pre- and post- conditioning agents: reperfusion-injury of the heart rev...
8585863 - Effects of anesthesia and k+ atp channel blockade on interstitial adenosine accumulatio...
23358103 - Nitric oxide donor agents for the treatment of ischemia/reperfusion injury in human sub...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  40     ISSN:  1401-7431     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-02     Completed Date:  2007-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
Department of Cardiology, Shandong Provincial Hospital of Shandong University, Jinan, 250021, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Coronary Circulation
Extremities / physiology*
Ischemic Preconditioning
Models, Animal
Myocardial Infarction / pathology*,  prevention & control*
Myocardial Reperfusion Injury / pathology*,  prevention & control*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  What is a normal lactate level during cardiopulmonary bypass?
Next Document:  Relationships between nitric oxide-mediated endothelial function, eNOS coupling and blood pressure r...