Document Detail

Limb allotransplantation in rats: combined immunosuppression by FK-506 and 15-deoxyspergualin.
MedLine Citation:
PMID:  10357540     Owner:  NLM     Status:  MEDLINE    
The immunosuppressive effect of combined therapy using FK-506 and 15-deoxyspergualin was investigated in rat limb allotransplantation. The right hindlimb of an inbred Dark Agouti rat (RT1a) was transplanted to a Lewis rat (RT1l) and observed for 120 days. Eighty-eight transplantations were performed. Rejection of the grafts was evaluated histologically as well as macroscopically. A pathologic grading system was used to rate the severity of rejection. Limb survival time in Lewis rats receiving FK-506 therapy for days was significantly prolonged by combined therapy with 15-deoxyspergualin. Histologic study showed practically no rejection in all the graft-composing tissues except the skin and bone marrow, in which there was rejection. These results suggest that tissues like bone, cartilage, and muscle may survive transplantation with short-term combination FK-506 and 15-deoxyspergualin therapy even after withdrawal of both agents.
K Muramatsu; K Doi; S Kawai
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of hand surgery     Volume:  24     ISSN:  0363-5023     ISO Abbreviation:  J Hand Surg Am     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-08     Completed Date:  1999-07-08     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  7609631     Medline TA:  J Hand Surg Am     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  586-93     Citation Subset:  IM    
Department of Orthopaedic Surgery, Yamaguchi University School of Medicine, Japan.
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MeSH Terms
Drug Therapy, Combination
Femur / pathology
Graft Survival*
Guanidines / therapeutic use*
Hindlimb / transplantation*
Immunosuppressive Agents / therapeutic use*
Muscle, Skeletal / pathology
Rats, Inbred Lew
Skin / pathology
Tacrolimus / therapeutic use*
Transplantation, Homologous
Reg. No./Substance:
0/Guanidines; 0/Immunosuppressive Agents; 109581-93-3/Tacrolimus; 84937-45-1/gusperimus

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