| Limb Lead Interchange in Thorough QT/QTc Studies. | |
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MedLine Citation:
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PMID: 21209246 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The investigators analyzed 85133 electrocardiograms (ECGs) recorded in 484 subjects from 5 thorough QT/QTc studies (3 using Holter devices, 2 using 12-lead ECGs) for inadvertent limb lead interchanges using a dedicated quality control process in a central ECG laboratory. Limb lead interchanges were present in 2919 (3.4%) ECGs in 17.9% of subjects and were more frequent with Holter devices (7.5% vs 0.8%, P < .0001), where leads remain connected for prolonged periods, affecting data from several time points. Left arm-left leg interchange was seen in 54% of 12-lead ECGs and right arm-left arm interchange in 38%. The ECG device itself could identify 21.7% of interchanges, whereas experienced readers blinded to subject and visit identified 79% of interchanges; 21% of interchanges were identified only during the quality control process. If correctly identified, QT measurement could be performed in a precordial lead. If undiagnosed, incorrect QT interval measurements and morphological diagnosis may confound results. |
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Authors:
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Vaibhav Salvi; Dilip R Karnad; Gopi Krishna Panicker; Snehal Kothari; Pooja Hingorani; Mili Natekar; Vaibhav Mahajan; Dhiraj Narula |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-5 |
Journal Detail:
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Title: Journal of clinical pharmacology Volume: - ISSN: 1552-4604 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0366372 Medline TA: J Clin Pharmacol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Quintiles Cardiac Safety Services. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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