Document Detail

Limb Apraxia in Multiple Sclerosis: Prevalence and Impact on Manual Dexterity and Activities of Daily Living.
MedLine Citation:
PMID:  22464095     Owner:  NLM     Status:  Publisher    
Kamm CP, Heldner MR, Vanbellingen T, Mattle HP, Müri R, Bohlhalter S. Limb apraxia in multiple sclerosis: prevalence and impact on manual dexterity and activities of daily living. OBJECTIVE: To evaluate the prevalence and impact of limb apraxia on manual dexterity and activities of daily living (ADLs) in patients with multiple sclerosis (MS). DESIGN: Survey. SETTING: University hospital. PARTICIPANTS: Consecutive patients (N=76) with clinically isolated syndrome, relapsing-remitting multiple sclerosis (RRMS), secondary progressive multiple sclerosis (SPMS) or primary progressive multiple sclerosis (PPMS), Expanded Disability Status Scale (EDSS) score from 0 to 6.5, and aged from 18 to 70 years were included. INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Apraxia was assessed by the apraxia screen of TULIA (AST). The relationship of apraxia with ADLs and manual dexterity was evaluated using a dexterity questionnaire and the coin rotation task, respectively. RESULTS: Overall, limb apraxia was found in 26.3% of patients (mean AST score ± SD, 7.3±1.3; cutoff <9). Apraxia was significantly correlated with higher EDSS scores, longer disease duration, and higher age with the EDSS being predictive. Furthermore, patients with SPMS and PPMS were more apraxic than patients with RRMS. Finally, limb apraxia was significantly associated with impaired ADLs and manual dexterity. CONCLUSIONS: Limb apraxia is a frequent and clinically significant symptom contributing to disability in MS. It should therefore be evaluated and possibly treated, particularly in patients with MS reporting manual difficulties in everyday life.
Christian P Kamm; Mirjam R Heldner; Tim Vanbellingen; Heinrich P Mattle; René Müri; Stephan Bohlhalter
Related Documents :
11585505 - Detection of pinpoint tenderness on the appendix under ultrasonography is useful to con...
18406245 - Insulin resistance, premature adrenarche, and a risk of the polycystic ovary syndrome (...
9740435 - Malignancy may adversely influence the quality and behaviour of oocytes.
17415505 - Accurate diagnosis of acute abdomen in fmf and acute appendicitis patients: how can we ...
24877055 - The association among antioxidant enzymes, autoantibodies, and disease severity score i...
21721825 - Mitochondrial function and tissue vitality: bench-to-bedside real-time optical monitori...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-28
Journal Detail:
Title:  Archives of physical medicine and rehabilitation     Volume:  -     ISSN:  1532-821X     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-4-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985158R     Medline TA:  Arch Phys Med Rehabil     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 the American Congress of Rehabilitation Medicine. Published by Elsevier Inc. All rights reserved.
Department of Neurology, Inselspital, Bern University Hospital, Bern, Switzerland; University of Bern, Bern, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Rollator Use Does Not Consistently Change the Metabolic Cost of Walking in People With Chronic Obstr...
Next Document:  The expression of interleukin-12 is increased by MAP kinase phosphatase-1 through a mechanism relate...