Document Detail

Lignans and human health.
MedLine Citation:
PMID:  17943494     Owner:  NLM     Status:  MEDLINE    
This review focuses on the possible role in human health of the consumption of lignan-rich foods. Most of the plant lignans in human foods are converted by the intestinal microflora in the upper part of the large bowel to enterolactone and enterodiol, called mammalian or enterolignans. The protective role of these compounds, particularly in chronic Western diseases, is discussed. Evidence suggests that fiber- and lignan-rich whole-grain cereals, beans, berries, nuts, and various seeds are the main protective foods. Many factors, in addition to diet, such as intestinal microflora, smoking, antibiotics, and obesity affect circulating lignan levels in the body. Lignan-rich diets may be beneficial, particularly if consumed for life. Experimental evidence in animals has shown clear anticarcinogenic effects of flaxseed or pure lignans in many types of cancer. Many epidemiological results are controversial, partly because the determinants of plasma enterolactone are very different in different countries. The source of the lignans seems to play a role because other factors in the food obviously participate in the protective effects. The results are promising, but much work is still needed in this area of medicine.
Herman Adlercreutz
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Critical reviews in clinical laboratory sciences     Volume:  44     ISSN:  1040-8363     ISO Abbreviation:  Crit Rev Clin Lab Sci     Publication Date:  2007  
Date Detail:
Created Date:  2007-10-18     Completed Date:  2008-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914816     Medline TA:  Crit Rev Clin Lab Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  483-525     Citation Subset:  IM    
Institute for Preventive Medicine, Nutrition and Cancer, Folkhälsan Research Center, Finland.
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MeSH Terms
4-Butyrolactone / analogs & derivatives,  chemistry,  metabolism,  pharmacology
Cardiovascular Diseases / prevention & control
Cereals / chemistry,  metabolism
Colorectal Neoplasms / prevention & control
Dietary Fiber* / pharmacology
Endometrial Neoplasms / prevention & control
Food Habits / physiology*
Health Status*
Isoflavones / chemistry,  pharmacology
Lignans / chemistry,  metabolism*,  pharmacology*
Phytoestrogens / pharmacology
Plants, Edible* / chemistry,  metabolism
Prostatic Neoplasms / prevention & control
Seeds / chemistry,  metabolism
Vegetables / chemistry,  metabolism
Reg. No./Substance:
0/Isoflavones; 0/Lignans; 0/Phytoestrogens; 76543-15-2/2,3-bis(3'-hydroxybenzyl)butyrolactone; 76543-16-3/2,3-bis(3'-hydroxybenzyl)butane-1,4-diol; 96-48-0/4-Butyrolactone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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