| Lignans from Santalum album and their cytotoxic activities. | |
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MedLine Citation:
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PMID: 20410650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A new neolignan, (7R,8R)-5-O-demethylbilagrewin (1), together with four known lignans (2-5), were isolated from the heartwood of Santalum album (Santalaceae). The structure of 1 was determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and A549 human lung adenocarcinoma cells. Compounds 1 and 2 exhibited cytotoxicity against HL-60 cells with IC(50) values of 1.5+/-0.02 and 4.3+/-0.13 microM, and against A549 cells with IC(50) values of 13.6+/-0.32 and 19.9+/-1.27 microM, respectively. The aldehyde group of 1 and 2 was revealed to be a structural requirement for the appearance of cytotoxicity in this type of lignans. These tumor cell deaths were shown to be mediated through induction of apoptosis. |
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Authors:
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Yukiko Matsuo; Yoshihiro Mimaki |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemical & pharmaceutical bulletin Volume: 58 ISSN: 1347-5223 ISO Abbreviation: Chem. Pharm. Bull. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-22 Completed Date: 2010-07-27 Revised Date: 2011-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0377775 Medline TA: Chem Pharm Bull (Tokyo) Country: Japan |
Other Details:
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Languages: eng Pagination: 587-90 Citation Subset: IM |
Affiliation:
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School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. matsuoy@toyaku.ac.jp |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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drug therapy Antineoplastic Agents, Phytogenic / chemistry, isolation & purification*, pharmacology* Apoptosis / drug effects Cell Line, Tumor Cytotoxins / chemistry, isolation & purification, pharmacology DNA Fragmentation / drug effects Humans Leukemia / drug therapy Lignans / chemistry, isolation & purification*, pharmacology* Lung Neoplasms / drug therapy Molecular Structure Neoplasms / drug therapy* Santalum / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents, Phytogenic; 0/Cytotoxins; 0/Lignans |
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