Document Detail


Lignans from Santalum album and their cytotoxic activities.
MedLine Citation:
PMID:  20410650     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A new neolignan, (7R,8R)-5-O-demethylbilagrewin (1), together with four known lignans (2-5), were isolated from the heartwood of Santalum album (Santalaceae). The structure of 1 was determined by analysis of extensive spectroscopic data. The isolated compounds and derivatives were evaluated for their cytotoxic activities against HL-60 human promyelocytic leukemia cells and A549 human lung adenocarcinoma cells. Compounds 1 and 2 exhibited cytotoxicity against HL-60 cells with IC(50) values of 1.5+/-0.02 and 4.3+/-0.13 microM, and against A549 cells with IC(50) values of 13.6+/-0.32 and 19.9+/-1.27 microM, respectively. The aldehyde group of 1 and 2 was revealed to be a structural requirement for the appearance of cytotoxicity in this type of lignans. These tumor cell deaths were shown to be mediated through induction of apoptosis.
Authors:
Yukiko Matsuo; Yoshihiro Mimaki
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemical & pharmaceutical bulletin     Volume:  58     ISSN:  1347-5223     ISO Abbreviation:  Chem. Pharm. Bull.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-22     Completed Date:  2010-07-27     Revised Date:  2011-03-08    
Medline Journal Info:
Nlm Unique ID:  0377775     Medline TA:  Chem Pharm Bull (Tokyo)     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  587-90     Citation Subset:  IM    
Affiliation:
School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan. matsuoy@toyaku.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / drug therapy
Antineoplastic Agents, Phytogenic / chemistry,  isolation & purification*,  pharmacology*
Apoptosis / drug effects
Cell Line, Tumor
Cytotoxins / chemistry,  isolation & purification,  pharmacology
DNA Fragmentation / drug effects
Humans
Leukemia / drug therapy
Lignans / chemistry,  isolation & purification*,  pharmacology*
Lung Neoplasms / drug therapy
Molecular Structure
Neoplasms / drug therapy*
Santalum / chemistry*
Chemical
Reg. No./Substance:
0/Antineoplastic Agents, Phytogenic; 0/Cytotoxins; 0/Lignans

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