| Lighting a path to pigmentation: mechanisms of MITF induction by UV. | |
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MedLine Citation:
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PMID: 20973930 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While sunlight is important for life, ultraviolet radiation (UVR) can have harmful and mutagenic effects. This duality is particularly relevant to human skin, in which UVR both participates in evolutionarily important photochemical reactions yet may act as a potential carcinogen. UVR can upregulate production of melanin, the "tanning response" that serves a photoprotective function. This genetic program is centrally tuned by the transcription factor MITF, a master regulator of melanogenesis and melanocyte function. In this review, we discuss the myriad consequences of UV exposure for skin homeostasis, highlighting the diverse pathways activated by this ultraviolet radiation. |
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Authors:
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Jue J Liu; David E Fisher |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: 23 ISSN: 1755-148X ISO Abbreviation: Pigment Cell Melanoma Res Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-10-26 Completed Date: 2011-02-04 Revised Date: 2011-04-13 |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 741-5 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Cutaneous Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Humans Microphthalmia-Associated Transcription Factor / genetics*, metabolism Models, Biological Skin Pigmentation / genetics, radiation effects* Ultraviolet Rays* |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR043369-16/AR/NIAMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Microphthalmia-Associated Transcription Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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