Document Detail


Light- and temperature-induced degradation of fumagillin
MedLine Citation:
PMID:  12891898     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The antibiotic fumagillin with amebicidal and fungicidal effects isolated from Aspergillus fumigatus is the only presently known agent for the treatment of life threatening serious microsporidiosis occurring in patients with AIDS. Fumagillin and its degradation products were measured by HPLC at given time intervals after storage under defined conditions (temperature, relative humidity). Significant degradation took place even in samples stored in freezer; therefore fumagillin drug substance should be stored below -60 degrees C. Light also induced a degradation process in fumagillin, thus it is proposed to be stored and transported in brown glass.
Authors:
Gabriella Agner; Andrea Gyórbíró; István Valkó; Lelle Vasvári-Debreczy; Anna Szabó; Gyula Farkas; Judit Halász; Benjámin Podányi; János Brlik; Kálmán Simon; Istvan Hermecz
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  Acta pharmaceutica Hungarica     Volume:  73     ISSN:  0001-6659     ISO Abbreviation:  Acta Pharm Hung     Publication Date:  2003  
Date Detail:
Created Date:  2003-08-01     Completed Date:  2003-12-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0414322     Medline TA:  Acta Pharm Hung     Country:  Hungary    
Other Details:
Languages:  hun     Pagination:  41-5     Citation Subset:  IM    
Affiliation:
Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt., Budapest, Tó u. 1-5.-1045.
Vernacular Title:
Fumagillin hó és fény hatására történó bomlásának vizsgálata.
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MeSH Terms
Descriptor/Qualifier:
Amebicides / chemistry,  therapeutic use
Anti-Bacterial Agents / chemistry,  therapeutic use
Cyclohexanes
Drug Stability
Fatty Acids, Unsaturated / chemistry*,  radiation effects,  therapeutic use
Humans
Light
Sesquiterpenes
Thermodynamics
Chemical
Reg. No./Substance:
0/Amebicides; 0/Anti-Bacterial Agents; 0/Cyclohexanes; 0/Fatty Acids, Unsaturated; 0/Sesquiterpenes; 23110-15-8/fumagillin
Comments/Corrections
Erratum In:
Acta Pharm Hung.2003;73(2):135

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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