Document Detail


Light-stimulated release of taurine from retinas of kainic acid-treated chicks.
MedLine Citation:
PMID:  7264653     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The light-stimulated release of [3H]taurine from chick retina was studied in chicks intraocularly injected with kainic acid (60 nmol). This treatment produced a loss of more than 80% of the inner nuclear and the inner synaptic layers, sparing the outer retinal layers. Concomitantly, the treatment produced a marked decrease of endogenous GABA and glycine but not of taurine. The activity of glutamate decarboxylase was also markedly decreased in the kainic acid-treated retinas. The release of [3H]taurine, either spontaneous or stimulated by light, was unaffected by the treatment. These results suggest that the light-stimulated efflux of taurine occurs from the retinal layers which are not affected by the kainic acid treatment.
Authors:
H Pasantes-Morales; O Quesada; A Cárabez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  36     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-10-25     Completed Date:  1981-10-25     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1583-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / metabolism
Animals
Chickens
Glutamate Decarboxylase / metabolism
Kainic Acid / pharmacology*
Light*
Photoreceptor Cells / drug effects,  metabolism
Pyrrolidines / pharmacology*
Retina / drug effects,  metabolism*
Taurine / metabolism*
Grant Support
ID/Acronym/Agency:
5ROI EY 02540-02/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Pyrrolidines; 107-35-7/Taurine; 487-79-6/Kainic Acid; EC 4.1.1.15/Glutamate Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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