| Light source spectrum strongly influences the in vitro estimation of sun protection factor. | |
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MedLine Citation:
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PMID: 22486409 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Irradiation from an artificial solar simulator that matches the relative cumulative erythema effectiveness (RCEE) of sunlight is used for in vivo sun protection factor (SPF) testing, whereas irradiation that matches the spectrum of natural sunlight is generally used for in vitro SPF testing. This study was designed to clarify whether this difference is important. Eight sunscreens spread on artificial substrates and several optical filters as sunscreen mimics were used. Their in vitro SPF values were evaluated using RCEE-compliant and natural sunlight spectrum-matching (NS) light sources in calculation. The calculated in vitro SPF values obtained using NS light (SPF [NS]) were lower than those obtained using RCEE light (SPF [RCEE]). The in vitro SPF [RCEE] values showed a better correlation and better agreement with in vivo SPF values, as compared with the in vitro SPF [NS] values. A marked difference between in vitro SPF values obtained with the two light sources in calculation was found for sunscreens showing low transmittance in the ultraviolet B (UVB) region. In order to obtain in vitro SPF values that correspond well to in vivo SPF values measured with currently accepted methodology, it is important to use an RCEE-compliant light source. © 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology. |
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Authors:
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Yoshimasa Miura; Sayaka Suzuki; Tetsuji Hirao; Masato Hatao |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-9 |
Journal Detail:
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Title: Photochemistry and photobiology Volume: - ISSN: 1751-1097 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376425 Medline TA: Photochem Photobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 Wiley Periodicals, Inc. Photochemistry and Photobiology © 2012 The American Society of Photobiology. |
Affiliation:
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Shiseido Research Center, 2-2-1, Hayabuchi, Tsuzuki-ku, Yokohama-shi, Japan 224-8558. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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