| Light shadowing effect of large breast lesions imaged by optical tomography in reflection geometry. | |
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MedLine Citation:
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PMID: 20615005 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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When a large, highly absorbing breast lesion is imaged by optical tomography in reflection geometry, most of the photons are absorbed by the top portion of the lesion. As a result, the lower portion of the lesion is not quantified correctly. This posterior light shadowing effect is similar to the sound shadowing effect frequently seen in pulse-echo ultrasound images. The presence of significant posterior shadowing of a lesion in ultrasound images suggests malignance. The light shadowing effect due to optical contrast is characterized using a simple measure and validated by the Monte Carlo photon-tracking method and phantom experiments. Clinical examples of large malignant and benign lesions are presented to demonstrate the shadowing effect and the utility of the measure. Understanding and quantifying the shadowing effect due to optical contrast is important for characterizing larger malignant cancers from benign lesions. |
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Authors:
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Chen Xu; Quing Zhu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of biomedical optics Volume: 15 ISSN: 1560-2281 ISO Abbreviation: J Biomed Opt Publication Date: 2010 May-Jun |
Date Detail:
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Created Date: 2010-07-09 Completed Date: 2010-10-29 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 9605853 Medline TA: J Biomed Opt Country: United States |
Other Details:
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Languages: eng Pagination: 036003 Citation Subset: IM |
Affiliation:
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University of Connecticut, Department of Electrical and Computer Engineering, 371 Fairfield Road, Storrs, Connecticut 06269, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Breast Neoplasms / pathology* Computer Simulation Female Humans Image Processing, Computer-Assisted / methods* Monte Carlo Method Phantoms, Imaging Photons Reproducibility of Results Spectroscopy, Near-Infrared Tomography, Optical / methods* Ultrasonography, Mammary |
| Grant Support | |
ID/Acronym/Agency:
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R01EB002136/EB/NIBIB NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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