| Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis. | |
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MedLine Citation:
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PMID: 19412313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Present techniques for prenatal diagnosis are invasive and present significant risks of fetal loss. Noninvasive prenatal diagnosis utilizing fetal nucleated red blood cells (fNRBC) circulating in maternal peripheral blood has received attention, since it poses no risk to the fetus. However, because of the failure to find broadly applicable identifiers that can differentiate fetal from adult NRBC, reliable detection of viable fNRBC in amounts sufficient for clinical use remains a challenge. In this Letter we show that fNRBC light-scattering spectroscopic signatures may lead to a clinically useful method of minimally invasive prenatal genetic testing. |
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Authors:
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Kee-Hak Lim; Saira Salahuddin; Le Qiu; Hui Fang; Edward Vitkin; Ionita C Ghiran; Mark D Modell; Tamara Takoudes; Irving Itzkan; Eugene B Hanlon; Benjamin P Sachs; Lev T Perelman |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Optics letters Volume: 34 ISSN: 0146-9592 ISO Abbreviation: Opt Lett Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-04 Completed Date: 2009-07-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7708433 Medline TA: Opt Lett Country: United States |
Other Details:
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Languages: eng Pagination: 1483-5 Citation Subset: IM |
Affiliation:
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Biomedical Imaging and Spectroscopy Laboratory, Department of ObGyn and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Erythroblasts / cytology Erythrocytes / cytology* Female Fetus / cytology* Humans Light* Pregnancy Prenatal Diagnosis / methods* Scattering, Radiation* Spectrum Analysis / methods* |
| Grant Support | |
ID/Acronym/Agency:
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RR017361/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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