Document Detail

Light-scattering spectroscopy differentiates fetal from adult nucleated red blood cells: may lead to noninvasive prenatal diagnosis.
MedLine Citation:
PMID:  19412313     Owner:  NLM     Status:  MEDLINE    
Present techniques for prenatal diagnosis are invasive and present significant risks of fetal loss. Noninvasive prenatal diagnosis utilizing fetal nucleated red blood cells (fNRBC) circulating in maternal peripheral blood has received attention, since it poses no risk to the fetus. However, because of the failure to find broadly applicable identifiers that can differentiate fetal from adult NRBC, reliable detection of viable fNRBC in amounts sufficient for clinical use remains a challenge. In this Letter we show that fNRBC light-scattering spectroscopic signatures may lead to a clinically useful method of minimally invasive prenatal genetic testing.
Kee-Hak Lim; Saira Salahuddin; Le Qiu; Hui Fang; Edward Vitkin; Ionita C Ghiran; Mark D Modell; Tamara Takoudes; Irving Itzkan; Eugene B Hanlon; Benjamin P Sachs; Lev T Perelman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Optics letters     Volume:  34     ISSN:  0146-9592     ISO Abbreviation:  Opt Lett     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-04     Completed Date:  2009-07-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708433     Medline TA:  Opt Lett     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1483-5     Citation Subset:  IM    
Biomedical Imaging and Spectroscopy Laboratory, Department of ObGyn and Reproductive Biology, Beth Israel Deaconess Medical Center, Harvard University, Boston, Massachusetts 02215, USA.
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MeSH Terms
Erythroblasts / cytology
Erythrocytes / cytology*
Fetus / cytology*
Prenatal Diagnosis / methods*
Scattering, Radiation*
Spectrum Analysis / methods*
Grant Support

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