Document Detail

Light modulates leptin and ghrelin in sleep-restricted adults.
MedLine Citation:
PMID:  22988459     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Acute and chronic sleep restrictions cause a reduction in leptin and an increase in ghrelin, both of which are associated with hunger. Given that light/dark patterns are closely tied to sleep/wake patterns, we compared, in a within-subjects study, the impact of morning light exposures (60 lux of 633-nm [red], 532-nm [green], or 475-nm [blue] lights) to dim light exposures on leptin and ghrelin concentrations after subjects experienced 5 consecutive days of both an 8-hour (baseline) and a 5-hour sleep-restricted schedule. In morning dim light, 5-hour sleep restriction significantly reduced leptin concentrations compared to the baseline, 8-hour sleep/dim-light condition (t(1,32) = 2.9; P = 0.007). Compared to the 5-hour sleep/dim-light condition, the red, green, and blue morning light exposures significantly increased leptin concentrations (t(1,32) = 5.7; P < 0.0001, t(1,32) = 3.6; P = 0.001, and t(1,32) = 3.0; P = 0.005, resp.). Morning red light and green light exposures significantly decreased ghrelin concentrations (t(1,32) = 3.3; P < 0.003 and t(1,32) = 2.2; P = 0.04, resp.), but morning blue light exposures did not. This study is the first to demonstrate that morning light can modulate leptin and ghrelin concentrations, which could have an impact on reducing hunger that accompanies sleep deprivation.
Mariana G Figueiro; Barbara Plitnick; Mark S Rea
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Publication Detail:
Type:  Journal Article     Date:  2012-08-14
Journal Detail:
Title:  International journal of endocrinology     Volume:  2012     ISSN:  1687-8345     ISO Abbreviation:  Int J Endocrinol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-18     Completed Date:  2012-09-19     Revised Date:  2013-04-02    
Medline Journal Info:
Nlm Unique ID:  101516376     Medline TA:  Int J Endocrinol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  530726     Citation Subset:  -    
Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180-3352, USA.
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