Document Detail


Light microscopic histology of achilles tendon ruptures. A comparison with unruptured tendons.
MedLine Citation:
PMID:  11101109     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We studied biopsies from the Achilles tendons of patients undergoing open repair for a subcutaneous rupture of their Achilles tendons (27 men, 11 women; mean age, 45.3 +/- 13.8 years) and specimens of Achilles tendons from persons with no known tendon ailments (43 men, 3 women; mean age, 64.2 +/- 9.7 years). Histologic examination was performed using stained slides that were interpreted using a semiquantitative grading scale assessing fiber structure and arrangement, rounding of the nuclei, regional variations in cellularity, increased vascularity, decreased collagen stainability, hyalinization, and glycosaminoglycan. We gave up to three marks for each of these variables, with 0 being normal and 3 being maximally abnormal. All the histology slides were assessed twice in a blinded manner; the agreement between two readings ranged from 0.56 to 0.87 (kappa statistics). The score of ruptured tendons was significantly greater than the average score of control tendons (20.5 +/- 3.6 versus 6.5 +/- 2.1), and there was significantly higher degeneration in the ruptured tendons. Nonruptured Achilles tendons, even at an advanced age, and ruptured Achilles tendons are clearly part of two distinct populations. Using these staining techniques, light microscopic degeneration is not a feature of tendons from healthy, older persons.
Authors:
N Maffulli; V Barrass; S W Ewen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of sports medicine     Volume:  28     ISSN:  0363-5465     ISO Abbreviation:  Am J Sports Med     Publication Date:    2000 Nov-Dec
Date Detail:
Created Date:  2001-03-14     Completed Date:  2001-05-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7609541     Medline TA:  Am J Sports Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-63     Citation Subset:  IM    
Affiliation:
Department Orthopaedic Surgery, University of Aberdeen, Foresterhill, Scotland.
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MeSH Terms
Descriptor/Qualifier:
Achilles Tendon / injuries*,  pathology*,  surgery
Adult
Biopsy
Chi-Square Distribution
Female
Humans
Male
Middle Aged
Rupture / pathology,  surgery
Staining and Labeling
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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