Document Detail

Light-mediated control of rhodopsin movement in mosquito photoreceptors.
MedLine Citation:
PMID:  23035078     Owner:  NLM     Status:  MEDLINE    
Multiple mechanisms contribute to a photoreceptor's ability to adapt to ambient light conditions. The mosquito Aedes aegypti expresses the long-wavelength rhodopsin Aaop1 in all R1-R6 photoreceptors and most R8 photoreceptors. These photoreceptors alter the cellular location of Aaop1 and reorganize their photosensitive rhabdomeric membranes on a daily basis. During daylight periods, Aaop1 is excluded from the light-sensitive rhabdomeres and localized to multivesicular bodies (MVBs) within the photoreceptor cytoplasm. In the dark, Aaop1 accumulates in the rhabdomeres and no Aaop1-containing MVBs are present in the cytoplasm. Manipulation of light treatments shows the cellular movement of Aaop1 in and out of the rhabdomere is directly controlled by light. In a separate process, the photoreceptors reduce Aaop1 protein content during a time period spanning from late afternoon into the first 2 h of the dark period. Aaop1 levels then gradually increase through the dark period and remain high following movement of Aaop1 to the cytoplasm at dawn. These results demonstrate that mosquito photoreceptors control rhodopsin availability during the daily light-dark cycle by novel mechanisms not discerned from analysis of traditional invertebrate models. These mechanisms will maximize a photoreceptor's light sensitivity range and therefore may be common in organisms active in low light conditions.
Xiaobang Hu; Matthew T Leming; Alexander J Metoxen; Michelle A Whaley; Joseph E O'Tousa
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of neuroscience : the official journal of the Society for Neuroscience     Volume:  32     ISSN:  1529-2401     ISO Abbreviation:  J. Neurosci.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-04     Completed Date:  2013-01-17     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  8102140     Medline TA:  J Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13661-7     Citation Subset:  IM    
Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
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MeSH Terms
Aedes / physiology*
Circadian Rhythm / physiology
Cytoplasm / metabolism
Insect Proteins / metabolism*
Microscopy, Immunoelectron
Photoreceptor Cells, Invertebrate / metabolism,  radiation effects*,  ultrastructure
Protein Transport / radiation effects
Rhodopsin / metabolism*
Grant Support
Reg. No./Substance:
0/Insect Proteins; 9009-81-8/Rhodopsin

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