Document Detail

Light- and electron-microscopic studies of intracytoplasmic acidophilic granules in the human locus ceruleus and substantia nigra.
MedLine Citation:
PMID:  6278812     Owner:  NLM     Status:  MEDLINE    
Using the brains of 30 patients with mental and neurologic disorders, we studied the intracytoplasmic acidophilic granules in neurons of the substantia nigra and locus ceruleus by light and electron microscopy. The granules were present in all 30 brains, including those with no recognizable pathologic change, there was no correlation between their appearance and the age, sex, disease of, or the medication received by, the patients. In four electron-microscopically examined brains, we noted many small, round electron-dense bodies in the perikarya and neuronal processes of the substantia nigra and locus ceruleus. The bodies were packed tightly within a double membrane; in shape, size, and distribution in the neuronal cytoplasm, they corresponded to acidophilic granules. Some mitochondrial matrices contained one or more similar, but smaller inclusion bodies; large bodies pushed aside the mitochondrial cristae. We conclude that the acidophilic granules represent high developed forms of mitochondrial inclusions.
S Sekiya; M Tanaka; S Hayashi; S Oyanagi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neuropathologica     Volume:  56     ISSN:  0001-6322     ISO Abbreviation:  Acta Neuropathol.     Publication Date:  1982  
Date Detail:
Created Date:  1982-05-21     Completed Date:  1982-05-21     Revised Date:  2007-11-09    
Medline Journal Info:
Nlm Unique ID:  0412041     Medline TA:  Acta Neuropathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  78-80     Citation Subset:  IM    
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MeSH Terms
Child, Preschool
Inclusion Bodies / ultrastructure*
Locus Coeruleus / ultrastructure*
Microscopy, Electron
Middle Aged
Mitochondria / ultrastructure
Substantia Nigra / ultrastructure*

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