| Light and electron-microscopic studies on guinea pig hearts after perfusion with nitro-blue tetrazolium (NBT). | |
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MedLine Citation:
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PMID: 65824 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Guinea pig hearts isolated by the Langendorff technique were perfused with a nitro-blue tetrazolium salt solution. In spite of a homogeneous dark-blue staining at the macroscopic examination, light-microscopic studies showed a spotty staining of the myocardial fibers. Since no microscopic alterations were found which could explain the unstained areas, ultramicroscopic studies were undertaken. At ultrastructural level, striking alterations of myocardial cells were observed. They consisted of mitochondrial lesions, alterations of the transversal tubuli, and intercalated discs. Arteriolar narrowing and capillary edema were found, suggesting that pathological changes in the microcirculation could be a possible reason for the spotty staining of the myocardial fibers. Some speculations on the nature and localization of the formazan granules are also reported. |
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Authors:
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L H Roesch; J Wichmann; G Arnold |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Virchows Archiv. A, Pathological anatomy and histology Volume: 373 ISSN: 0340-1227 ISO Abbreviation: Virchows Arch A Pathol Anat Histol Publication Date: 1977 Feb |
Date Detail:
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Created Date: 1977-04-25 Completed Date: 1977-04-25 Revised Date: 2008-02-20 |
Medline Journal Info:
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Nlm Unique ID: 7505137 Medline TA: Virchows Arch A Pathol Anat Histol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 67-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Coronary Disease / pathology* Coronary Vessels / ultrastructure Guinea Pigs Microscopy, Electron Mitochondria / ultrastructure Myocardium / pathology* Nitroblue Tetrazolium / diagnostic use* Staining and Labeling Tetrazolium Salts / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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0/Tetrazolium Salts; 298-83-9/Nitroblue Tetrazolium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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