Document Detail

Light and electron microscopic investigation of the rat placenta after cadmium administration during pregnancy.
MedLine Citation:
PMID:  3177889     Owner:  NLM     Status:  MEDLINE    
The morphology of the rat placenta was studied after exposure to cadmium chloride during pregnancy, using optimal fixation conditions. In contrast to previous observations, no differences were observed after cadmium administration in relative volume densities of trophoblastic tissue, maternal lacunae, fetal capillaries and connective tissue, nor in trophoblastic thickness or other morphometric features. At the ultrastructural level, the amount of glycogen in trophoblast layer II was elevated in cadmium exposed rats, but other electron microscopic features (amount and localization of lipid, degenerative vesicles, thickness and general appearance of the trophoblastic and endothelial layers and thickening or multiplication of the basal lamina) were not changed. Results obtained from the present experiments do not support the suggestion that cadmium is responsible for structural changes in the placentae of human smokers.
W Hazelhoff Roelfzema; U Zahn-Breidenbach; J H Copius Peereboom-Stegeman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anatomy and embryology     Volume:  178     ISSN:  0340-2061     ISO Abbreviation:  Anat. Embryol.     Publication Date:  1988  
Date Detail:
Created Date:  1988-11-15     Completed Date:  1988-11-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7505194     Medline TA:  Anat Embryol (Berl)     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  345-51     Citation Subset:  IM    
Laboratory of Histology and Cell Biology, University of Amsterdam, The Netherlands.
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MeSH Terms
Cadmium / toxicity*
Microscopy, Electron
Placenta / drug effects*,  pathology,  ultrastructure
Pregnancy, Animal / drug effects*
Rats, Inbred Strains
Reg. No./Substance:

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