Document Detail

Light and electron microscopic evidence for projections from the thalamic nucleus rotundus to targets in the basal ganglia, the dorsal ventricular ridge, and the amygdaloid complex in a lizard.
MedLine Citation:
PMID:  10906699     Owner:  NLM     Status:  MEDLINE    
To elucidate the organization and evolution of the tectorotundotelencephalic pathways in birds and reptiles, we reinvestigated at both light and electron microscopic levels the efferent projections of nucleus rotundus in a lizard, using the sensitive tracer biotinylated dextran amine. Our results indicate that nucleus rotundus projects to targets in the basal ganglia (lateral parts of striatum and olfactory tubercle and possibly the globus pallidus), the anterior dorsal ventricular ridge (ADVR), and the amygdaloid complex (the central and possibly lateral amygdaloid nuclei). In these targets, the rotundal axon terminals establish asymmetric, presumably excitatory synaptic contacts, usually with dendrites of local cells. In the ADVR, the rotundal projection terminates in two separate radial regions showing distinct cytoarchitecture: 1) a dorsolateral region that extends radially from the dorsolateral ADVR ventricular surface to the ventral part of the lateral cortex and 2) the lateral part of a ventromedial region that extends radially from the dorsomedial and medial ADVR ventricle to a superficial area interposed between the dorsolateral ADVR and the striatum. These two ADVR regions have different connections with the thalamus and telencephalon, which suggests that they may be involved in different degrees of integration. Our study also suggests that the rotundal projection to the ventromedial ADVR field of lizards may be comparable to the rotundoectostriatal/periectostriatal projection of birds. The connections and pathways involving nucleus rotundus suggest that this nucleus conveys visual information which may play a role in visuomotor, emotional, and visceral functions.
S Guirado; J C Dávila; M A Real; L Medina
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  424     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  2000 Aug 
Date Detail:
Created Date:  2000-09-07     Completed Date:  2000-09-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  216-32     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Departamento de Biología Celular y Genética, Facultad de Ciencias, Universidad de Málaga, Málaga 29071, Spain.
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MeSH Terms
Amygdala / physiology,  ultrastructure*
Axons / physiology,  ultrastructure
Basal Ganglia / physiology,  ultrastructure*
Emotions / physiology
Lizards / anatomy & histology*,  physiology
Microscopy, Electron
Neural Pathways / physiology,  ultrastructure*
Psychomotor Performance / physiology
Synapses / physiology,  ultrastructure
Thalamus / cytology*,  physiology

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