| Light- and dark-adapted electroretinograms (ERGs) and ocular pigmentation: comparison of brown- and blue-eyed cohorts. | |
| | |
MedLine Citation:
|
PMID: 20665068 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study characterizes differences in human ERGs based on ocular pigmentation. Light- and dark-adapted luminance-response (LR) series for a-, b- and i-waves and light-adapted oscillatory potentials (OPs) were recorded in 14 healthy volunteers (7 blue-eyed Caucasians; 7 brown-eyed Asians, aged 20-22 years). Amplitude interpolations were by logistic growth (Naka-Rushton), Gaussian or the combined 'photopic hill' functions. Implicit times (IT) for dark-adapted a- and b-waves, and for light-adapted a-, b- and i-waves were earlier in the blue-eyed group than in the brown-eyed group across all flash strengths (P < 0.05). For dark-adapted ERGs, saturated a-wave amplitude was larger for blue eyes (397 vs. 318 μV, P < 0.05) as was the a-wave to strong flash (10 cd·s/m(2); 357 vs. 293 μV, P < 0.05) and the b-wave to ISCEV standard 0.01 (354 vs. 238 μV, P < 0.05). Light-adapted b-waves for midrange flash stimuli were much larger for the blue-eyed group (photopic hill, Gaussian peak: 155 vs. 82 μV, P < 0.001) with no difference in saturated amplitudes. Similarly, interpolated i-wave amplitudes were larger (48 vs. 18 μV, P < 0.01). For a light-adapted 2.6 stimulus, a- and b-waves were larger for the blue-eyed group (52 vs. 39 μV; 209 vs. 133 μV, P < 0.01) as were OP4 and OP5 (37.2 vs. 15.6 μV; 47.5 vs. 22.2 μV, P < 0.01), but OP1-OP3 did not differ. ERGs have shorter ITs in people with blue irides than in those with dark pigmentation. Amplitude differences are highly non-linear and substantially larger from eyes with light pigmentation for components thought to be associated with the OFF retinal pathways. |
| | |
Authors:
|
Abdlsaed Al Abdlseaed; Yvonne McTaggart; Thomas Ramage; Ruth Hamilton; Daphne L McCulloch |
Related Documents
:
|
8334928 - Accommodative response changes with age measured by pattern electroretinogram. 1707808 - Effect of spatial frequency on simultaneous recorded steady-state pattern electroretino... 14691148 - Absence of functional and structural abnormalities associated with expression of egfp i... 960358 - Pars plana virectomy. preoperative evaluation. 16914608 - Complex spike-event pattern of transient on-off retinal ganglion cells. 14583508 - Light production by the arm tips of the deep-sea cephalopod vampyroteuthis infernalis. |
Publication Detail:
|
Type: Comparative Study; Journal Article Date: 2010-07-28 |
Journal Detail:
|
Title: Documenta ophthalmologica. Advances in ophthalmology Volume: 121 ISSN: 1573-2622 ISO Abbreviation: Doc Ophthalmol Publication Date: 2010 Oct |
Date Detail:
|
Created Date: 2010-09-17 Completed Date: 2011-01-13 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0370667 Medline TA: Doc Ophthalmol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 135-46 Citation Subset: IM |
Affiliation:
|
Department of Vision Sciences, Glasgow Caledonian University, Glasgow, G4 0BA, UK. saed.alabdlseaed@gcal.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Dark Adaptation* Electroretinography* Eye Color / physiology* Humans Oscillometry Photic Stimulation Retina / physiology* Young Adult |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ecohealth is coming to (London) town-and a Blackbird sings in Russell Square!
Next Document: Assessment of GABARAP self-association by its diffusion properties.