| Light chain type ratio of IgA-producing cells in human jejunal biopsies. | |
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MedLine Citation:
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PMID: 1168135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As part of an investigation on a possible relationship between the serum IgA and the immunoglobulins synthesized by the plasma cells in the intestinal mucosa, immunoglobulin-producing cells in human jejunal biopsies were characterized by class and type of intracellular immunoglobulins. In biopsy Specimens from 22 patients, with various diagnoses except multiple myeloma, the average percentage of IgA-producing cells was 83 percent, that of IgG-producing cells 5 percent and that of IgM-producing cells 12 percent, with a wide range for individual patients. For the IgA-producing cells the kappa/lambda ratio was determined and the average ratio was found to be 63 : 37, within a very limited range for individual patients. There was no correlation between the relative number of IgA-producing cells in the biopsy specimens and the IgA concentration in the serum. Additionally biopsy specimens from 3 patients with a monoclonal immunoglobulin-A component in their serum were studied. In one of those there was a remarkable shift in the kappa/lambda ratio, indicating that the light chain distribution of the intestinal IgA plasma cells was affected by the lympho-proliferative process. |
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Authors:
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N A Mul |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 5 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1975 Feb |
Date Detail:
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Created Date: 1975-06-27 Completed Date: 1975-06-27 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Animals Antibody-Producing Cells / metabolism* Biopsy Child, Preschool Female Goats / immunology Humans Immunoglobulin A / biosynthesis* Jejunum / cytology, immunology* Male Middle Aged Rabbits / immunology |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulin A |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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